TUT1 antibody (Middle Region)

Catalog No. ABIN405252

The Rabbit Polyclonal anti-TUT1 antibody (ABIN405252) specifically detects TUT1 in WB. The antibody is reactive with Human samples.

Quick Overview for TUT1 antibody (Middle Region) (ABIN405252)

Target: TUT1 (Terminal Uridylyl Transferase 1, U6 SnRNA-Specific (TUT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TUT1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TUT1 Antibody

Binding Specificity: Middle Region

Purpose: TUT1 Antibody - middle region

Sequence: EGAGGGAGTR AGWLATEAQV TQELKGLSGG EERPETEPLL SFVASVSPAD

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against TUT1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TUT1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP39567-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for TUT1

Target: TUT1 (Terminal Uridylyl Transferase 1, U6 SnRNA-Specific (TUT1))

Alternative Name: TUT1

Background:

Background Information: TUT1 is a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase. TUT1 specifically adds and removes nucleotides from the 3' end of small nuclear RNAs and select mRNAs and may function in controlling gene expression and cell proliferation. TUT1 specifically catalyzes uridylylation of U6 snRNA (RNU6, MIM 180692) and is essential for cell proliferation (Trippe et al., 2006 [PubMed 16790842]).[supplied by OMIM].

Gene Name: Terminal uridylyl transferase 1, U6 snRNA-specific

Alternative Symbols: PAPD2, RBM21, TENT1, URLC6, TUTase, STARPAP

Protein Name: Speckle targeted PIP5K1A-regulated poly(A) polymerase

Molecular Weight: 94kDa

Gene ID: 64852

NCBI Accession: NP_073741

UniProt: A8K995