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Details for Product No. ABIN405496

ATG4 Autophagy Related 4 Homolog A (S. Cerevisiae) (ATG4A) (N-Term) antibody

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Antigen
Synonyms APG4A, AUTL2, AI627006, AV169859, Apg4a, Atg4al, Autl2, Aut2a, zgc:111958, apg4a, autl2, F6E13.27
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Zebrafish (Danio rerio), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN405496
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-ATG4A antibody: synthetic peptide directed towards the N terminal of human ATG4A
Sequence DAGWGCMLRCGQMMLAQALICRHLGRDWSWEKQKEQPKEY QRILQCFLDR
Predicted Reactivity Bovine : 100%, Horse : 100%, Human : 100%, Pig : 100%, Rabbit : 100%, Dog : 92%, Mouse : 92%, Zebrafish : 78%
Characteristics This is a rabbit polyclonal antibody against ATG4A. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name ATG4A
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. ATG4A is a member of the autophagin protein family. ATG4A is also designated as a member of the C-54 family of cysteine proteases.Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.
Molecular Weight 45kDa
Gene ID 115201
NCBI Accession NP_443168, NM_052936
UniProt Q8WYN0
Research Area Cancer, Autophagy, Proteolysis / Ubiquitin
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-ATG4A antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Scherz-Shouval, Shvets, Fass et al.: "Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4." in: The EMBO journal, Vol. 26, Issue 7, pp. 1749-60, 2007 (PubMed).

Alternatives for antigen "ATG4 Autophagy Related 4 Homolog A (S. Cerevisiae) (ATG4A)", type "Antibodies"
Hosts (51), (2), (1)
Reactivities (52), (26), (14), (12)
Applications (29), (20), (16), (16), (11), (5), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (12), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1)
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