ATG4 Autophagy Related 4 Homolog A (S. Cerevisiae) (ATG4A) (N-Term) antibody

Details for Product No. ABIN405496
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Antigen
Synonyms apg4a, autl2, F6E13.27, APG4A, zgc:111958, Aut2a, AUTL2, AI627006, AV169859, Apg4a, Atg4al, Autl2, Atg4a
Epitope
N-Term
(5), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Zebrafish (Danio rerio), Human
(52), (30), (13), (12)
Host
Rabbit
(50), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(31), (23), (14), (11), (10), (9), (4), (3), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN405496
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human ATG4A
Sequence DAGWGCMLRC GQMMLAQALI CRHLGRDWSW EKQKEQPKEY QRILQCFLDR
Predicted Reactivity Bovine : 100 %, Horse : 100 %, Human : 100 %, Pig : 100 %, Rabbit : 100 %, Dog : 90 %, Mouse : 90 %, Zebrafish : 70 %
Characteristics This is a rabbit polyclonal antibody against ATG4A. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name ATG4A
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. ATG4A is a member of the autophagin protein family. ATG4A is also designated as a member of the C-54 family of cysteine proteases.Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.
Molecular Weight 45 kDa
Gene ID 115201
NCBI Accession NP_443168, NM_052936
UniProt Q8WYN0
Research Area Cancer, Autophagy, Proteolysis / Ubiquitin
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 398 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications Scherz-Shouval, Shvets, Fass et al.: "Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4." in: The EMBO journal, Vol. 26, Issue 7, pp. 1749-60, 2007 (PubMed).

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