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Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase (MARCH1) antibody

Antigen

Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase (MARCH1)
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
1 reference available
Catalog no. ABIN405536
Quantity 50 µg
Price 317.90 $   Plus shipping costs $45.00
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anti-Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase (MARCH1) antibody

Additional Information
Application Details Publications Images Alternatives back to top

Alternative name MARCH1 / RNF171
Gene ID MARCH1
UniProt Q8TCQ1-2
Immunogen The immunogen for anti-MARCH1 antibody: synthetic peptide directed towards the N terminal of human MARCH1
Sequence LQASSPTTGTAPRSQSRLSVCPSTQDICRICHCEGDEESP LITPCRCTGT
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Format Lyophilized
Reconstitution Add 50 µl of distilled water. Final anti-MARCH1 antibody concentration is 1 mg/ml.
Description MARCH1 is an E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC, CD86 and FAS, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Characteristics Antigen Size: 272 amino acids
Molecular Weight 31kDa

Application Details
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Application Notes WB Suggested Anti-MARCH1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Human Muscle.
Purification Affinity Purified
Buffer PBS
Storage (Long Term) For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Storage (Short Term) Any unfrozen and/or unused material can be stored at 4°C for short term use (< 1 week), and should not be re-frozen.
Restrictions For Research Use only

Publications
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Product De Gassart, Camosseto, Thibodeau et al.: "MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 9, pp. 3491-6, 2008 (PubMed).

Alternatives
Application Details Publications Images back to top

Alternatives for antigen "Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase (MARCH1)", type "Antibodies"
Hosts Rabbit (21), Goat (3), Mouse (1)
Reactivities Human (21), Mouse (Murine) (18), Rat (Rattus) (18)
Applications Flow Cytometry (FACS) (15), Immunofluorescence (IF) (15), ELISA (8), Western Blotting (WB) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (3), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)
Epitopes Center (1), Internal Region (1), N-Term (1)