Hyaluronidase-1 (HYAL1) (N-Term) antibody

Details for Product No. ABIN406142
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Antigen
Synonyms HYAL-1, LUCA1, NAT6, Hya1, Hyal-1
Epitope
N-Term
(10), (8), (8), (6), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Rat (Rattus), Mouse (Murine), Pig (Porcine), Cow (Bovine), Human
(54), (22), (19), (5), (5), (4)
Host
Rabbit
(45), (11), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(40), (30), (15), (14), (10), (6), (3), (3), (2), (2), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN406142
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human HYAL1
Sequence WNANTQWCLE RHGVDVDVSV FDVVANPGQT FRGPDMTIFY SSQLGTYPYY
Predicted Reactivity Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rat : 100 %, Pig : 90 %, Rabbit : 90 %, Dog : 80 %, Bovine : 80 %
Characteristics This is a rabbit polyclonal antibody against HYAL1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name HYAL1
Background HYAL1 is a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in HYAL1 are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. HYAL1 is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for HYAL1.This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
Molecular Weight 45 kDa
Gene ID 3373
NCBI Accession NP_695014, NM_153282
UniProt Q12794
Research Area Cancer, Extracellular Matrix
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 405 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Hyaluronidase-1 (HYAL1) (N-Term) antibody anti-Hyaluronidase-1 (HYAL1) (N-Term) antibody
anti-Hyaluronidase-1 (HYAL1) (N-Term) antibody (2) anti-Hyaluronidase-1 (HYAL1) (N-Term) antibody (Image 2)
anti-Hyaluronidase-1 (HYAL1) (N-Term) antibody (3) anti-Hyaluronidase-1 (HYAL1) (N-Term) antibody (Image 3)
anti-Hyaluronidase-1 (HYAL1) (N-Term) antibody (4) Host: Rabbit
Target Name: HYAL1
Sample Tissue: Human Fetal Lung
Antibody Dilution: 1.0 µg/mL
anti-Hyaluronidase-1 (HYAL1) (N-Term) antibody (5) Host: Rabbit
Target Name: HYAL1
Sample Tissue: Human Fetal Brain
Antibody Dilution: 1.0 µg/mL
Background publications Poola, Abraham, Marshalleck et al.: "Molecular risk assessment for breast cancer development in patients with ductal hyperplasias." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 4, pp. 1274-80, 2008 (PubMed).

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