SCP2 antibody (Middle Region)

Catalog No. ABIN406612

Product Details anti-SCP2 Antibody

Target: SCP2 (Sterol Carrier Protein 2 (SCP2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCP2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: NHKHSVNNPY SQFQDEYSLD EVMASKEVFD FLTILQCCPT SDGAAAAILA

Predicted Reactivity: Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against SCP2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SCP2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 322 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SCP2

Target: SCP2 (Sterol Carrier Protein 2 (SCP2))

Alternative Name: SCP2 (SCP2 Products)

Synonyms: NLTP antibody, NSL-TP antibody, SCP-2 antibody, SCP-CHI antibody, SCP-X antibody, SCPX antibody, AA409774 antibody, AA409893 antibody, C76618 antibody, C79031 antibody, ns-LTP antibody, NSLIPTR antibody, SCPx antibody, MGC77634 antibody, zgc:77634 antibody, SCP2 antibody, MGC108409 antibody, ATSCP2 antibody, MBD2.8 antibody, MBD2_8 antibody, STEROL CARRIER PROTEIN 2 antibody, PLTP antibody, zgc:101621 antibody, sterol carrier protein 2 antibody, sterol carrier protein 2, liver antibody, sterol carrier protein 2a antibody, sterol carrier protein 2 L homeolog antibody, phospholipid transfer protein homolog1 antibody, uncharacterized LOC101116445 antibody, sterol carrier protein 2b antibody, SCP2 antibody, Scp2 antibody, scp2a antibody, scp2.L antibody, scp2 antibody, CC1G_13192 antibody, plt1 antibody, LOC101116445 antibody, scp2b antibody

Background: SCP2 protein is thought to be an intracellular lipid transfer protein. SCP2 is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis.This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.
Alias Symbols: DKFZp686C12188, DKFZp686D11188, NLTP, NSL-TP, SCPX, SCP-2, SCP-X, SCP-CHI
Protein Interaction Partner: TRIP13, UBC, PEX5, MPLKIP, MRRF, SUGP1, MRPS28, TBL2, SRRM2, RAB31, SEPT9, TIMM44, ECI2, SCO2, AGPS, STX7, UBL4A, VDAC3, VDAC2, RRBP1, RBMS1, NDUFA7, IDH3G, HSD17B4, ACAA1, RAB8A, ELAVL1, CACNA1A, ACAA2, EHHADH, CAV1, ACOX1, PITPNA,
Protein Size: 322

Molecular Weight: 35 kDa

Gene ID: 6342

NCBI Accession: NM_001007098, NP_001007099

UniProt: Q6NXF4

Pathways: C21-Steroid Hormone Metabolic Process, Monocarboxylic Acid Catabolic Process