ARP1 Actin-Related Protein 1 Homolog A, Centractin alpha (Yeast) (ACTR1A) (Middle Region) antibody

Details for Product No. ABIN406684
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Antigen
Synonyms ACTR1A, arp1, centractin, ctrn1, ARP1, CTRN1, Arp1, alpha-Arp1
Epitope
Middle Region
(15), (8), (7), (2), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Xenopus laevis, Zebrafish (Danio rerio), Cow (Bovine), Human, Chicken
(31), (26), (19), (13), (13), (12)
Host
Rabbit
(30), (4), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(24), (17), (10), (4), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN406684
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Immunogen Synthetic peptide directed towards the middle region of human ACTR1A
Sequence AIKERACYLS INPQKDETLE TEKAQYYLPD GSTIEIGPSR FRAPELLFRP
Predicted Reactivity African clawed frog : 100 %, Bovine : 100 %, Chicken : 100 %, Horse : 100 %, Human : 100 %, Pig : 100 %, Rabbit : 100 %
Characteristics This is a rabbit polyclonal antibody against ACTR1A. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name ACTR1A
Background ACTR1A is a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60 % identical at the amino acid level to conventional actin.This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60 % identical at the amino acid level to conventional actin.
Molecular Weight 41 kDa
Gene ID 10121
NCBI Accession NP_005727, NM_005736
UniProt P61163
Research Area Signaling, Cytoskeleton, Microfilaments
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 376 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-ARP1 Actin-Related Protein 1 Homolog A, Centractin alpha (Yeast) (ACTR1A) (Middle Region) antibody WB Suggested Anti-ACTR1A Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: MCF7 cell lysate
Background publications Sugarbaker, Richards, Gordon et al.: "Transcriptome sequencing of malignant pleural mesothelioma tumors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 9, pp. 3521-6, 2008 (PubMed).

Validation Images
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