SUV420H2/KMT5C antibody (Middle Region)

Catalog No. ABIN453403

Product Details anti-SUV420H2/KMT5C Antibody

Target: SUV420H2/KMT5C (SUV420H2) (Suppressor of Variegation 4-20 Homolog 2 (SUV420H2))

Binding Specificity: Middle Region

Reactivity: Mouse, Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUV420H2/KMT5C antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to SUV4-20H2.

Purification: Saturated Ammonium Sulfate (SAS) precipitation

Immunogen: KLH conjugated synthetic peptide selected from the Center region of human SUV420H2

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SUV420H2/KMT5C

Target: SUV420H2/KMT5C (SUV420H2) (Suppressor of Variegation 4-20 Homolog 2 (SUV420H2))

Alternative Name: SUV420H2 / KMT5C (SUV420H2 Products)

Synonyms: zgc:162876 antibody, KMT5C antibody, BC024816 antibody, Suv4-20h2 antibody, lysine methyltransferase 5C antibody, suppressor of variegation 4-20 homolog 2 (Drosophila) antibody, lysine (K)-specific methyltransferase 5C L homeolog antibody, KMT5C antibody, kmt5c antibody, SUV420H2 antibody, kmt5c.L antibody, Kmt5c antibody

Background: SUV420H2 is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).Synonyms: Histone-lysine N-methyltransferase SUV420H2, Lysine N-methyltransferase 5C, Suppressor of variegation 4-20 homolog 2

Gene ID: 84787

NCBI Accession: NP_116090

UniProt: Q86Y97