Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (C-Term) antibody

Details for Product No. ABIN453450
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms cb358, wu:fc55h08, UCHL1, UCH-L1, park5, pgp9.5, uch-l1, MGC132191, uchl1, AW822034, C88048, PGP 9.5, PGP9.5, R75593, UCHL-1, gad, PARK5, PGP95, Uch-L1
Epitope
C-Term
(39), (20), (13), (12), (7), (6), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(226), (75), (72), (25), (21), (14), (4), (4), (3), (2), (2), (1), (1), (1), (1)
Host
Rabbit
(139), (84), (14), (12), (7), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(201), (101), (66), (64), (31), (20), (17), (10), (4), (3), (2), (1)
Pubmed 5 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN453450
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen KLH conjugated synthetic peptide selected from the C-terminal region of human UCHL1
Specificity This antibody reacts to UCHL1 / PGP9.5.
Purification Affinity chromatography on Protein A
Alternative Name UCHL1 / PGP9.5
Background UCHL1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is present in all neurons.
Alternate names: Neuron cytoplasmic protein 9.5, PGP 9.5, UCH-L1, Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin thioesterase L1
Gene ID 7345
NCBI Accession NP_004172
UniProt P09936
Research Area Tags/Labels, Cell/Tissue Markers
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Saigoh, Wang, Suh et al.: "Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice." in: Nature genetics, Vol. 23, Issue 1, pp. 47-51, 1999 (PubMed).

Caballero, Resto, Patturajan et al.: "Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)." in: Oncogene, Vol. 21, Issue 19, pp. 3003-10, 2002 (PubMed).

Liu, Fallon, Lashuel et al.: "The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility." in: Cell, Vol. 111, Issue 2, pp. 209-18, 2002 (PubMed).

Nishikawa, Li, Kawamura et al.: "Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants." in: Biochemical and biophysical research communications, Vol. 304, Issue 1, pp. 176-83, 2003 (PubMed).

Maraganore, de Andrade, Lesnick et al.: "Complex interactions in Parkinson's disease: a two-phased approach." in: Movement disorders : official journal of the Movement Disorder Society, Vol. 18, Issue 6, pp. 631-6, 2003 (PubMed).

Validation Images
Did you look for something else?
back to top