GLP2R antibody (Extracellular Domain, N-Term)

Catalog No. ABIN497997

Product Details anti-GLP2R Antibody

Target: GLP2R (Glucagon-Like Peptide 2 Receptor (GLP2R))

Binding Specificity: Extracellular Domain, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLP2R antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Reacts with Glucagon-Like Peptide 2 Receptor (GLP2R).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography.

Immunogen: Synthetic peptide corresponding to N-terminal extracellular domain of Human GLP2R. .Remarks: The immunizing peptide shows 81% identity (87% similarity) with Rat.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry on Formalin Fixed Paraffin Embedded Tissues: 5-10 μg/mL(Requires pretreatment with Proteinase K).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.6 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Target Details for GLP2R

Target: GLP2R (Glucagon-Like Peptide 2 Receptor (GLP2R))

Alternative Name: GLP2 Receptor (GLP2R Products)

Synonyms: 9530092J08Rik antibody, GLP-2 antibody, glucagon like peptide 2 receptor antibody, glucagon-like peptide 2 receptor antibody, GLP2R antibody, Glp2r antibody

Background: GLP2R, a Glucagon Receptor, is closely related to the Glucagon Receptor and to the GLP1 Receptor. The glucagon-like peptides (GLP-1 and GLP-2) are proglucagon-derived peptides cosecreted from gut endocrine cells in response to nutrient ingestion. The actions of GLP-2 are mediated by the GLP-2 receptor expressed on subsets of enteric nerves and enteroendocrine cells in the stomach and small and large intestine. Activation of GLP2R signaling promotes expansion of the mucosal epithelium indirectly via activation of growth and anti-apoptotic pathways. GLP2R, through its ligand glucagon-like peptide 2 (GLP2), has been shown to prevent intestinal hypoplasia resulting from total parenteral nutrition. GLP2R has been reported primarily in the gastrointestinal tract, including intestine and stomach. In rats, GLPR2 has been shown in brain and lung. An EST has been isolated from a lung cancer library.Synonyms: GLP-2-R, GLP-2R, GLP2R, Glucagon-like peptide 2 receptor

Gene ID: 9340

NCBI Accession: NP_004237

UniProt: O95838

Pathways: Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, cAMP Metabolic Process, Feeding Behaviour