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CD4 Molecule (CD4) antibody

Antigen

CD4 Molecule (CD4)
Synonyms CD4, MGC165891, cd4, CD4mut, L3T4, Ly-4, p55, W3/25
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Application
Alternatives Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Catalog no. ABIN498108
Quantity 100 µg  (1.0 mg/ml)  (Variants)
Price 340.00 $   Plus shipping costs $35.00
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Additional Information
Application Details Alternatives Secondary Antibodies Variants back to top

Characteristics Synonyms: T4/Leu-3, T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3
Alternative name CD4
Gene ID 920
Swiss-Prot P01730
Cross-Reactivity Human, Mouse (Murine)
Description The T cell receptor (TCR) is a heterodimer composed of either α and β or γ and δ chains. CD3 chains and the CD4 or CD8 co-receptors are also required for efficient signaltransduction through the TCR. The TCR is expressed on T helper and T cytotoxic cells thatcan be distinguished by their expression of CD4 and CD8, T helper cells express CD4proteins and T cytotoxic cells display CD8. CD4 is also expressed on cortical cells, maturemedullary thymocytes, microglial cells and dendritic cells. CD4 (also designated T4 andLeu 3) is a membrane glycoprotein that contains four extracellular immunoglobin-likedomains. The TCR in association with CD4 can bind class II MHC molecules presented bythe antigen-presenting cells. The CD4 protein functions by increasing the avidity of theinteraction between the TCR and an antigenclass II MHC complex. An additional role of CD4is to function as a receptor for HIV.
Specificity This antibody antibody detects endogenous levels of CD4 protein. Species: Human, Mouse. Others not tested.

Application Details
Alternatives Secondary Antibodies Variants back to top

Application Notes Western Blots: 1/500~1/1000. Immunohistochemistry: 1/50~1/200. Immunofluorescence: 1/50~1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Concentration 1.0 mg/ml
Purification Aff - Purified
Buffer Phosphate buffered saline (PBS), pH~7.2 containing 15 mM Sodium Azideas preservative.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Research Area Immunology, Adaptive Immunity, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only

Alternatives
Application Details Secondary Antibodies Variants back to top

Alternatives for antigen "CD4 Molecule (CD4)", type "Antibodies"
Hosts Mouse (445), Rat (208), Rabbit (67)
Reactivities Human (320), Mouse (Murine) (238), Rat (Rattus) (106), Dog (Canine) (44), Chicken (34), Cow (Bovine) (34), Sheep (Ovine) (24), Pig (Porcine) (22), Cat (Feline) (20), Rabbit (20), Bird (Avian) (8), Guinea Pig (8), Horse (Equine) (4), Duck (3), Monkey (3)
Applications Flow Cytometry (FACS) (602), Immunohistochemistry (Frozen Sections) (IHC (fro)) (149), Immunoprecipitation (IP) (93), Western Blotting (WB) (82), Immunofluorescence (IF) (52), ELISA (50), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (48), Functional Studies (Func) (35), Immunohistochemistry (IHC) (29), Immunocytochemistry (ICC) (16), Blocking Antibody (Inhibition) (11), Cytotoxicity Test (CyTox) (11), Enzyme Immunoassay (EIA) (9), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (4), Immunoelectron Microscopy (IEM) (2), Blocking Antibody (Inhibition) (1), ELISA (Detection) (1), Immunohistochemistry (Fixed) (IHC (fx)) (1), Neutralization (Neut) (1)
Conjugates FITC (116), PE (77), Biotin (71), APC (40), RPE (22), Cy5 (9), Cy5,PE (9), Cy5.5 (6), Cy7,PE (6), Alexa Fluor 488 (5), PE,Cy7 (5), HRP (4), PE,Cy5.5 (4), Pacific Blue (4), APC,Cy7 (3), PE,Cy5 (3), PerCP (3), SPRD (3), Alexa Flour 488 (2), Alexa Fluor 350 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), Alexa Fluor 700 (2), Cy3 (2), Cy7 (2), Gold (2), PE,Cy3 (2), RBITC (2), DY647 (1), Dyomics 647 (1), PE,DY590 (1), PE,DY647 (1), PE,Texas Red (TR) (1), PE-Dyomics 590 (1), PE-Dyomics 647 (1), PerCP,Cy5.5 (1), RPE,Cy5 (1), RPE,Cy7 (1)
Epitopes domain 1 (10), domain 2 (5), non-polymorphic (5)