ELAVL2 antibody, HEL-N1 antibody, HELN1 antibody, HUB antibody, Hub antibody, mel-N1 antibody, Elav2 antibody, Xel-1 antibody, el-1 antibody, elavl2 antibody, elrB antibody, hel-n1 antibody, heln1 antibody, hub antibody, p45 antibody, zgc:91918 antibody, ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) antibody, ELAV like RNA binding protein 2 antibody, ELAV like neuron-specific RNA binding protein 2 L homeolog antibody, ELAV like neuron-specific RNA binding protein 2 antibody, ELAVL2 antibody, Elavl2 antibody, elavl2.L antibody, elavl2 antibody
Background
The Elav-like genes encode for a family of RNA-binding proteins. Elav, a Drosophila protein and the first described member, is expressed immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. Several mammalian Elav-like proteins, designated HuC, HuD and Hel-N1, are also expressed in postmitotic neurons. An additional mammalian homolog, HuR, which is also designated HuA, is ubiquitously expressed and is also overexpressed in a wide variety of tumors. Characteristically, these homologs all contain three RNA recognition motifs (RRM), and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation.Synonyms: ELAV-like neuronal protein 1, ELAV-like protein 2, Hel-N1, Hu-antigen B, Nervous system-specific RNA-binding protein Hel-N1