SOX8 antibody

Catalog No. ABIN498428

Product Details anti-SOX8 Antibody

Target: SOX8 (SRY (Sex Determining Region Y)-Box 8 (SOX8))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOX8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of Sox-8/9/17/18 protein. (region surrounding Lys148)

Cross-Reactivity (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SOX8

Target: SOX8 (SRY (Sex Determining Region Y)-Box 8 (SOX8))

Alternative Name: SOX8 (SOX8 Products)

Synonyms: SRY-box 8 antibody, SRY box 8 antibody, SRY-box 8 L homeolog antibody, SRY (sex determining region Y)-box 8 antibody, SOX8 antibody, Sox8 antibody, sox8.L antibody

Background: Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. At present 30 Sox genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.Synonyms: SOX-17, SOX-18, SOX-8, SOX-9

Molecular Weight: approx. 47 kDa

Gene ID: 30812

NCBI Accession: NP_055402

UniProt: P57073

Pathways: Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development