INHBC antibody

Catalog No. ABIN498474

Product Details anti-INHBC Antibody

Target: INHBC (Inhibin, beta C (INHBC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INHBC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of Inhibin beta-C protein. (region surrounding Val129)

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography

Purity: > 95 % by SDS-PAGE

Application Details

Application Notes: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for INHBC

Target: INHBC (Inhibin, beta C (INHBC))

Alternative Name: Inhibin beta C Chain (INHBC) (INHBC Products)

Synonyms: IHBC antibody, inhibin beta C subunit antibody, inhibin beta-C antibody, INHBC antibody, Inhbc antibody

Background: The TGFbeta superfamily is composed of numerous growth and differentiation factors, including transforming growth factor beta (TGFbeta) 1, 2 and 3, growth/differentiation factor (GDF) 1 through 8, Mullerian inhibiting substance (MIS), bone morphogenic protein (BMP) 2 through 8, glial cell linederived neurotrophic factor (GDNF), inhibins (alpha, beta-A, beta-B and beta-C), Lefty and Nodal. Members of the TGFbeta superfamily are involved in embryonic development and adult tissue homeostasis. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins and activins are involved in regulating a number of functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth depending on their subunit composition. Activins oppose the funtions of inhibins. Inhibins are predominantly expressed in liver, uterus and ovary tissue, but also in benign prostatic hyperplasia. Inhibin A, a dimer of alpha and beta-A, and inhibin B, a dimer of alpha and beta-B, have been shown to inhibit the secretion of follicle stimulating hormone. Inhibin beta-C forms a homodimer and its expression is predominant in adult liver and in benign prostatic hyperplasia.Synonyms: Activin C, Activin beta-C chain

Molecular Weight: approx. 30 kDa

Gene ID: 3626

NCBI Accession: NP_005529

UniProt: P55103

Pathways: Peptide Hormone Metabolism, Hormone Activity