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Paxillin (PXN) (pTyr31) antibody

Antigen

Paxillin (PXN)
Synonyms FLJ16691, Pax, AW108311, AW123232, CG18061, CG18576, CT40481, CT42454, DPaxillin, DPxn, DPxn37, Dpax, PDLP, DmelCG31794, CG31794, LOC397826, wu:fw71f12, PXN, DKFZp469J2119, LOC100220858
Epitope
Alternatives

pTyr31
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Application
Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Catalog no. ABIN498711
Quantity 100 µg  (1,0 mg/ml)  (Variants)
Price 340.00 $   Plus shipping costs $35.00
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Additional Information
Application Details Alternatives Secondary Antibodies Variants back to top

Characteristics Synonyms: FLJ16691
Alternative name Paxillin / PXN
Gene ID 5829
Swiss-Prot P49023
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Description The effects of some oncogenes, growth factors and neuropeptides are mediated bytyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin cytoskeletal proteins. A rapid increase in tyrosine phosphorylation of paxillin, FAK and Crk-associated substrate(CAS) are prominent early events triggered by many G protein-coupled receptors. Inaddition to G protein-coupled receptors, Angiotensin IV (Ang IV), protein kinase C andother proteins can also mediate the tyrosine phosphorylation of paxillin. Paxillin must bindFAK for maximal phosphorylation in response to cell adhesion. FAK may function to directtyrosine phosphorylation of paxillin in the process of transformation by the Src oncogene.
Specificity P-Paxillin (pTyr31) pAb detects endogenous levels of p-Paxillin protein. Species: Human, Mouse, Rat. Others not tested.

Application Details
Alternatives Secondary Antibodies Variants back to top

Application Notes Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Concentration 1,0 mg/ml
Purification Aff - Purified
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Restrictions For Research Use only

Alternatives
Application Details Secondary Antibodies Variants back to top

Alternatives for antigen "Paxillin (PXN)", type "Antibodies"
Hosts Rabbit (100), Mouse (7)
Reactivities Human (101), Mouse (Murine) (48), Rat (Rattus) (47), Chicken (4), Dog (Canine) (3), Cow (Bovine) (1), Horse (Equine) (1), Monkey (1), Pig (Porcine) (1), Xenopus laevis (1)
Applications Western Blotting (WB) (82), Immunofluorescence (IF) (38), Immunohistochemistry (IHC) (26), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (22), Flow Cytometry (FACS) (18), Enzyme Immunoassay (EIA) (13), ELISA (10), Immunoprecipitation (IP) (6), ELISA (Detection) (3), Immunocytochemistry (ICC) (2), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
Epitopes pTyr118 (11), pTyr31 (9), pTyr88 (7), C-Term (2), Center (2), pSer178 (2), N-Term (1), Y118 (1), pSer83 (1)