CEP290 antibody

Catalog No. ABIN499044

The Rabbit Polyclonal anti-CEP290 antibody (ABIN499044) specifically detects CEP290 in WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for CEP290 antibody (ABIN499044)

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEP290 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CEP290 Antibody

Specificity: This antibody detects endogenous levels of CEP290 protein. (region surrounding Phe812)

Cross-Reactivity (Details): Species reactivity (tested):Human and Mouse.

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CEP290

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Alternative Name: CEP290

Background: CEP290 activates ATF4 mediated transcription and is required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells, may play a role in ciliary transport processes. CEP290 is ubiquitously expressed, strongly in placenta and weakly in brain. There are two named isoforms. Defects in CEP290 are a cause of Joubert syndrome type 5 (JBTS5) [MIM:610188], Senior-Loken syndrome type 6 (SLSN6) [MIM:610189], Leber congenital amaurosis type 10 (LCA10) [MIM:611755] and Meckel syndrome type 4 (MKS4) [MIM:611134]. Antibodies against CEP290 are present in sera from patients with cutaneous T cell lymphomas, but not in the healthy control population.Synonyms: CT87, Cancer/testis antigen 87, Centrosomal protein of 290 kDa, KIAA0373, NPHP6, Nephrocystin-6, Tumor antigen se2-2, se2-2

Molecular Weight: approx. 290 kDa

Gene ID: 80184

NCBI Accession: NP_079390

UniProt: O15078

Pathways: cAMP Metabolic Process, M Phase