CEP290 antibody (AA 950-1050)

Catalog No. ABIN7266277

This Rabbit Polyclonal antibody specifically detects CEP290 in WB. It exhibits reactivity toward Human.

Quick Overview for CEP290 antibody (AA 950-1050) (ABIN7266277)

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEP290 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CEP290 Antibody

Binding Specificity: AA 950-1050

Purpose: CEP290 Rabbit pAb

Sequence: QKVVDNSVSL SELELANKQY NELTAKYRDI LQKDNMLVQR TSNLEHLECE NISLKEQVES INKELEITKE KLHTIEQAWE QETKLGNESS MDKAKKSITN S

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 950-1050 of human CEP290 (NP_079390.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CEP290

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Alternative Name: CEP290

Background: This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer.,CEP290,3H11Ag,BBS14,CT87,JBTS5,LCA10,MKS4,NPHP6,POC3,SLSN6,rd16,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Neuroscience,CEP290

Molecular Weight: 180kDa/290kDa

Gene ID: 80184

UniProt: O15078

Pathways: cAMP Metabolic Process, M Phase