FX antibody, P35B antibody, SDR4E1 antibody, AI256181 antibody, Tstap35b antibody, p35b antibody, sdr4e1 antibody, TSTA3 antibody, zgc:101805 antibody, si:dkey-235d18none antibody, Fx antibody, tissue specific transplantation antigen P35B antibody, tissue specific transplantation antigen P35B L homeolog antibody, TSTA3 antibody, Tsta3 antibody, tsta3 antibody, tsta3.L antibody
Background
GDP-L-fucose synthetase (FX protein), also designated Tissue-specific transplantation antigen P35B or GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, belongs to the fucose synthetase family. FX is a red cell NADP(H)- binding protein that is important in leukocyte adhesion and trafficking processes. The FX protein, together with GDP-mannose 4,6-dehydratase, can convert GDP-mannose to GDP-L-fucose by catalyzing the two-step epimerase and reductase reactions. GDP-L-fucose is the substrate of several fucosyltransferases that function in the expression of many glycoconjugates such as blood group ABH antigens and developmental adhesion antigens. Defects in the gene encoding for the FX protein cause leukocyte adhesion deficiency (LAD).Synonyms: 5-epimerase-4-reductase, GDP-4-keto-6-deoxy-D-mannose-3, GDP-L-fucose synthetase, Protein FX, Red cell NADP(H)-binding protein, SDR4E1, Short chain dehydrogenase/reductase family 4E member 1