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Myosin VA (MYO5A) (Internal Region) antibody

Details for Product No. ABIN499147
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Antigen
Synonyms
myo5a, MGC53270, si:dkey-266j9.1, MYOA, MYO5A, D, Dop, Myh12, 9630007J19Rik, AI413174, AI661011, Dbv, MVa, Myo5, MyoVA, Sev-1, d, d-120J, flail, flr, DILUTE, myoxin), non-muscle, GS1, MYH12, MYO5, MYR ... show more
myo5a, MGC53270, si:dkey-266j9.1, MYOA, MYO5A, D, Dop, Myh12, 9630007J19Rik, AI413174, AI661011, Dbv, MVa, Myo5, MyoVA, Sev-1, d, d-120J, flail, flr, DILUTE, myoxin), non-muscle, GS1, MYH12, MYO5, MYR12 show less
Epitope
Internal Region
(6), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
(13), (10), (8), (2), (1)
Host
Goat
(13), (2), (2)
Clonality
Polyclonal
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA, Western Blotting (WB)
(17), (11), (3), (3), (1), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN499147
357.50 $
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Immunogen Peptide sequence from the internal region of the protein sequence according to NP_000250.3, NP_001135967.1. Genename: MYO5A
Sequence C-ETKQLELDLN
Specificity This antibody is expected to recognize both reported isoforms (NP_000250.3 and NP_001135967.1). Species Reactivity: Tested: Human, Mouse. Expected from sequence similarity: Rat, Bovine.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Alternative Name Myosin-Va
Background Myosin-Va has been implicated in the regulation of vesicle trafficking in neurons and melanocytes. It has been suggested that class V myosins associate with membrane vesicles through their C-terminal tails. Myosin V associates with synaptic vesicles and forms a stable complex with the synaptic vesicle membrane proteins, synaptobrevin II, and synaptophysin. The dilute Myo5a gene mutation in myosin Va leads to mental retardation, variable cellular immunodeficiency and impaired melanocyte function (pigmentary dilution), known as Griscelli syndrome in humans. Myosin Va regulates melanosome distribution along microfilaments. It is found in association with the centrosome at all stages of the cell cycle. In the interphase stage, myosin Va is found in pericentriolar material. During cell division, it is found in the cytoplasm and concentrates in a trail between migrating centrioles and in the mitotic spindle poles and spindle fibers.
Alternate names: Dilute myosin heavy chain, MYH12, MYO5A, Myosin heavy chain 12, Myoxin, non-muscle
Molecular Weight 215kDa (NP_000250.3).
Gene ID 4644
NCBI Accession NP_000250
UniProt Q9Y4I1
Application Notes Peptide ELISA: Limit Dilution: 1/8000. Western blot: 1-3 µg/ml. This antibody detects a band of ~200kDa in lysates of cell lineJurkat. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, pH~7.3 0.02% Sodium Azide 0.5% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Guey, García-Closas, Murta-Nascimento et al.: "Genetic susceptibility to distinct bladder cancer subphenotypes." in: European urology, Vol. 57, Issue 2, pp. 283-92, 2010 (PubMed).

Validation Images
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