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ACIN1 antibody (Apoptotic Chromatin Condensation Inducer 1) (Intermediate Domain)

Details for Product anti-ACIN1 Antibody No. ABIN499201, Supplier: Log in to see
Antigen
  • acinus
  • acinusb
  • fi14c05
  • wu:fe06a10
  • wu:fi14c05
  • acinusa
  • acinusl
  • ik:tdsubc_2g5
  • si:zc14a17.12
  • wu:fb04g06
  • wu:fb40f03
  • wu:fb68h03
  • wu:fb80f07
  • wu:fc12e10
  • xx:tdsubc_2g5
  • acn
  • ACINUS
  • ACN
  • fSAP152
  • 2610036I19Rik
  • 2610510L13Rik
  • Acinus
  • Acn
  • C79325
  • acinusL
  • acinusS
  • mKIAA0670
Epitope
Intermediate Domain
33
20
13
13
9
6
5
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
128
34
22
1
Host
Rabbit
123
9
Clonality
Polyclonal
Conjugate
This ACIN1 antibody is un-conjugated
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
112
45
24
17
13
12
12
5
4
4
3
2
1
Supplier
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Immunogen Human Acinus (Intermediate Domain) Peptide
Isotype IgG
Specificity Acinus antibody was raised against a peptide corresponding to amino acids 775 to 789 of Human AcinusL, 48 to 62 of human AcinusS', or 17 to 31 of human AcinusS, which differ from those of mouse Acinus by one amino acid .
Purification Affinity chromatography purified via peptide column
Alternative Name Acinus / ACIN1 (ACIN1 Antibody Abstract)
Background Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE . A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS (2).Synonyms: Apoptotic chromatin condensation inducer in the nucleus, KIAA0670
Gene ID 22985
UniProt Q9UKV3
Research Area Cell Cycle, Apoptosis/Necrosis
Application Notes ELISA. Western Blot: Acinus antibody can be used for detection of Acinus at 0.5 to 1 μg/mL. A 220 kDa band can be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunofluorescence (IF) image for anti-ACIN1 antibody (Apoptotic Chromatin Condensation Inducer 1) (Intermediate Domain) (ABIN499201) Immunocytochemistry of Acinus in K562 cells with AP30012PU-N Acinus antibody at 5 μg/ml.
Western Blotting (WB) image for anti-ACIN1 antibody (Apoptotic Chromatin Condensation Inducer 1) (Intermediate Domain) (ABIN499201) Western blot analysis of Acinus in K562 whole cell lysate with AP30012PU-N Acinus ant...
Background publications Sahara, Aoto, Eguchi et al.: "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation." in: Nature, Vol. 401, Issue 6749, pp. 168-73, 1999 (PubMed).

Zamzami, Kroemer: "Condensed matter in cell death." in: Nature, Vol. 401, Issue 6749, pp. 127-8, 1999 (PubMed).