ACVR1C/ALK7 antibody (N-Term)

Catalog No. ABIN499209

The Rabbit Polyclonal anti-ACVR1C/ALK7 antibody (ABIN499209) specifically detects ACVR1C/ALK7 in WB and EIA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for ACVR1C/ALK7 antibody (N-Term) (ABIN499209)

Target: ACVR1C/ALK7 (ACVR1C) (Activin Receptor Type 1C (ACVR1C))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACVR1C/ALK7 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-ACVR1C/ALK7 Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to ACVR1C near the amino terminus.

Purification: Affinity chromatography purified via peptide column

Immunogen: ACVR1C antibody was raised against a 15 amino acid peptide near the amino terminus of the human ACVR1C.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: ACVR1C antibody can be used for detection of ACVR1C at 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for ACVR1C/ALK7

Target: ACVR1C/ALK7 (ACVR1C) (Activin Receptor Type 1C (ACVR1C))

Background: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1C, also known as ALK7, is a type I activin receptor and plays a role in cell differentiation, growth arrest and apoptosis. ACVR1C can mediate signaling by ligans such as Nodal, GDF-1/3, activin B and activin AB, all of which can also signal through the ubiquitous activin type I receptor ACVR1B (also known as ALK4). ACVR1C is a novel marker specifically expressed during the late phase of adipocyte differentiation. ACVR1C is dispensable for mouse embryogenesis, which suggests alternative functions for this receptor in postnatal development and tissue homeostasis. ACVR1C plays an important role in regulating the functional plasticity of pancreatic islets, negatively affecting beta-cell function by mediating the effects of activin B on Ca2+ signaling. This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1B.Synonyms: ACTR-IC, ACTRIC, ALK7, Activin receptor-like kinase 7

Gene ID: 130399

NCBI Accession: NP_001104501

UniProt: Q8NER5

Pathways: Negative Regulation of Hormone Secretion, Positive Regulation of Endopeptidase Activity