ACVR1C/ALK7 antibody (C-Term)

Catalog No. ABIN6259759

Product Details anti-ACVR1C/ALK7 Antibody

Target: ACVR1C/ALK7 (ACVR1C) (Activin Receptor Type 1C (ACVR1C))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACVR1C/ALK7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: ACVR1C Antibody detects endogenous levels of total ACVR1C.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ACVR1C, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for ACVR1C/ALK7

Target: ACVR1C/ALK7 (ACVR1C) (Activin Receptor Type 1C (ACVR1C))

Alternative Name: ACVR1C (ACVR1C Products)

Synonyms: ACVRLK7 antibody, ALK7 antibody, Alk-7 antibody, C230097P10 antibody, Alk7 antibody, habrec1 antibody, activin A receptor type 1C antibody, activin A receptor, type IC antibody, ACVR1C antibody, Acvr1c antibody

Background:

Description: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Gene: ACVR1C

Molecular Weight: 55kDa

Gene ID: 130399

UniProt: Q8NER5

Pathways: Negative Regulation of Hormone Secretion, Positive Regulation of Endopeptidase Activity