Amyloid beta (A4) Precursor Protein (APP) (N-Term) antibody

Details for Product No. ABIN499321
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Antigen
Synonyms
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\\CG7727, EG:65F1.5, appl, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp, app, wu:fj34d10 ... show more
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\\CG7727, EG:65F1.5, appl, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp, app, wu:fj34d10, wu:fk65e12, zgc:85740, aaa, abeta, abpp, ad1, appi, ctfgamma, cvap, pn2 show less
Epitope
N-Term
(108), (78), (33), (31), (25), (13), (13), (10), (9), (8), (7), (7), (7), (6), (5), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(695), (355), (289), (212), (202), (197), (192), (71), (13), (12), (4), (2), (2), (1), (1)
Host
Rabbit
(499), (202), (41), (6), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(30), (26), (24), (17), (17), (17), (17), (17), (17), (17), (17), (9), (5), (5), (4), (4), (4), (4), (2), (2)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(477), (300), (185), (163), (158), (61), (47), (42), (26), (24), (7), (2), (2), (1), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN499321
Quantity 0.1 mg
Price
401.50 $   Plus shipping costs $45.00
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days

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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen APP antibody was raised against an 18 amino acid peptide near the amino terminus of human APP. (AP30073CP-N)
Isotype IgG
Specificity This antibody reacts to APP.
Purification Affinity chromatography purified via peptide column
Alternative Name Amyloid beta A4 protein / APP
Background Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The beta-amyloid protein precursor (APP) is cleaved by one of two beta-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimers disease patients’ brains. Recently, Death Receptor 6 (DR6) was found to interact with an amino-terminal fragment of the Beta- amyloid protein (N-APP) in neurons, activating a caspase 6-dependent apoptotic event leading to axonal degeneration and pruning during development, suggesting that these two proteins are involved in neural development and may possibly play a role in Alzheimers disease.
Alternate names: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II
Gene ID 1238255
NCBI Accession P05067
UniProt P05067
Research Area Neurology, Alzheimer's Disease
Application Notes ELISA. Western Blot: APP antibody can be used for detection of APP at 1 – 2 μg/ml. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Ponte, Gonzalez-DeWhitt, Schilling et al.: "A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors." in: Nature, Vol. 331, Issue 6156, pp. 525-7, 1988 (PubMed).

Nikolaev, McLaughlin, OLeary et al.: "APP binds DR6 to trigger axon pruning and neuron death via distinct caspases." in: Nature, Vol. 457, Issue 7232, pp. 981-9, 2009 (PubMed).

Hosts (499), (202), (41), (6), (2)
Reactivities (695), (355), (289), (212), (202), (197), (192), (71), (13), (12), (4), (2), (2), (1), (1)
Applications (477), (300), (185), (163), (158), (61), (47), (42), (26), (24), (7), (2), (2), (1), (1), (1), (1)
Conjugates (30), (26), (24), (17), (17), (17), (17), (17), (17), (17), (17), (9), (5), (5), (4), (4), (4), (4), (2), (2)
Epitopes (108), (78), (33), (31), (25), (13), (13), (10), (9), (8), (7), (7), (7), (6), (5), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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