beta-Site APP-Cleaving Enzyme 2 (BACE2) (N-Term) antibody

Details for Product No. ABIN499395
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Synonyms AEPLC, ALP56, ASP1, ASP21, BAE2, CEAP1, DRAP, 1110059C24Rik, AI850424, ARP1, CDA13
(31), (15), (15), (15), (12), (5), (5), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(140), (44), (43)
(148), (2), (1)
(9), (8), (4), (4), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(125), (73), (44), (24), (15), (10), (9), (7), (6), (6), (2), (2)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Human BACE2 (N-Terminus) Peptide
Isotype IgG
Specificity BACE2 antibody was raised against a synthetic peptide corresponding to amino acids 44 to 59 of human BACE2.
Purification Affinity chromatography purified via peptide column
Alternative Name BACE2 (BACE2 Antibody Abstract)
Background Accumulation of the amyloid-beta (alphabeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. alphabeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at beta-site and at a different site within alphabeta (8). BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', suggesting that BACE2 and alphabeta may also contribute to the pathogenesis of Down syndrome (6,7)Synonyms: AEPLC, ALP56, ASP1, ASP21, Aspartic-like protease 56 kDa, Aspartyl protease 1, Beta-secretase 2, Beta-site APP-cleaving enzyme 2, Down region aspartic protease, Memapsin-1, Membrane-associated aspartic protease 1
Gene ID 25825
UniProt Q9Y5Z0
Research Area Proteolysis / Ubiquitin, Alzheimer's Disease, Enzymes
Application Notes ELISA. Western Blot: BACE2 can be used for detection of BACE2 at 0.5 to 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-beta-Site APP-Cleaving Enzyme 2 (BACE2) (N-Term) antibody (ABIN499395) Immunohistochemistry of BACE2 in mouse heart with AP30112PU-N BACE2 antibody at 10 μg...
Western Blotting (WB) image for anti-beta-Site APP-Cleaving Enzyme 2 (BACE2) (N-Term) antibody (ABIN499395) Western blot analysis of BACE2 in human (A) and mouse (B) heart tissue lysates with A...
Background publications Hussain, Powell, Howlett et al.: "Identification of a novel aspartic protease (Asp 2) as beta-secretase." in: Molecular and cellular neurosciences, Vol. 14, Issue 6, pp. 419-27, 2000 (PubMed).

Sinha, Anderson, Barbour et al.: "Purification and cloning of amyloid precursor protein beta-secretase from human brain. ..." in: Nature, Vol. 402, Issue 6761, pp. 537-40, 1999 (PubMed).

Yan, Bienkowski, Shuck et al.: "Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity." in: Nature, Vol. 402, Issue 6761, pp. 533-7, 1999 (PubMed).

Vassar, Bennett, Babu-Khan et al.: "Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE." in: Science (New York, N.Y.), Vol. 286, Issue 5440, pp. 735-41, 1999 (PubMed).

Catalog No. ABIN499395
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