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Details for Product No. ABIN499397

beta-Site APP-Cleaving Enzyme 2 (BACE2) (C-Term) antibody

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Antigen
Synonyms AEPLC, ALP56, ASP1, ASP21, BAE2, CEAP1, DRAP, ARP1, CDA13, AI850424, 1110059C24Rik, bace2, MGC68881, MGC68482, BACE2
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN499397
Quantity 0.1 mg
Price
390.50 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 6 to 8 Business Days
Immunogen Human BACE2 (C-Terminus) Peptide (AP30113CP-N)
Isotype IgG
Specificity BACE2 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human BACE2.
Purification Affinity chromatography purified via peptide column
Alternative Name BACE2
Background Accumulation of the amyloid-beta (alphabetabeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. alphabeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). BACE/Asp2 is a novel transmembrane aspartic protease and co- localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at b-site and at a different site within alphabeta (8). BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region’, suggesting that BACE2 and alphabeta may also contribute to the pathogenesis of Down syndrome (6,7)
Alternate names: AEPLC, ALP56, ASP1, ASP21, Aspartic-like protease 56 kDa, Aspartyl protease 1, Beta- secretase 2, Beta-site APP-cleaving enzyme 2, Beta-site APP-cleaving enzyme 2, Down region aspartic protease, Memapsin-1, Membrane-associated aspartic protease 1
Gene ID 25825
NCBI Accession AAF17078
UniProt Q9Y5Z0
Research Area Proteolysis / Ubiquitin, Alzheimer's Disease, Enzymes
Application Notes ELISA. Western Blot: BACE2 antibody can be used for detection of BACE2 at 0.5 to 1 μg/ml. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Vassar, Bennett, Babu-Khan et al.: "Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE." in: Science (New York, N.Y.), Vol. 286, Issue 5440, pp. 735-41, 1999 (PubMed).

Yan, Bienkowski, Shuck et al.: "Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity." in: Nature, Vol. 402, Issue 6761, pp. 533-7, 1999 (PubMed).

Sinha, Anderson, Barbour et al.: "Purification and cloning of amyloid precursor protein beta-secretase from human brain." in: Nature, Vol. 402, Issue 6761, pp. 537-40, 1999 (PubMed).

Hussain, Powell, Howlett et al.: "Identification of a novel aspartic protease (Asp 2) as beta-secretase." in: Molecular and cellular neurosciences, Vol. 14, Issue 6, pp. 419-27, 2000 (PubMed).

Alternatives for antigen "beta-Site APP-Cleaving Enzyme 2 (BACE2)", type "Antibodies"
Hosts (90), (1), (1)
Reactivities (79), (36), (36), (12)
Applications (80), (43), (23), (21), (10), (3), (2), (2), (1), (1), (1)
Conjugates (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (14), (13), (9), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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