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beta-Site APP-Cleaving Enzyme 2 (BACE2) (C-Term) antibody

Details for Product No. ABIN499397, Supplier: Log in to see
Antigen
  • AEPLC
  • ALP56
  • ASP1
  • ASP21
  • BAE2
  • CEAP1
  • DRAP
  • 1110059C24Rik
  • AI850424
  • ARP1
  • CDA13
Epitope
C-Term
29
16
15
15
13
10
5
5
5
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
134
47
46
Host
Rabbit
143
2
1
Clonality
Polyclonal
Conjugate
Un-conjugated
9
8
4
4
4
3
2
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
113
69
38
24
17
12
7
5
3
2
1
Supplier
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Immunogen Human BACE2 (C-Terminus) Peptide
Isotype IgG
Specificity BACE2 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human BACE2.
Purification Affinity chromatography purified via peptide column
Alternative Name BACE2 (BACE2 Antibody Abstract)
Background Accumulation of the amyloid-beta (alphabetaβ) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. alphabeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2) (1-4). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1 (4-9). BACE2 also cleaves APP at b-site and at a different site within alphabeta (8). BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', suggesting that BACE2 and alphabeta may also contribute to the pathogenesis of Down syndrome (6,7)Synonyms: AEPLC, ALP56, ASP1, ASP21, Aspartic-like protease 56 kDa, Aspartyl protease 1, Beta-secretase 2, Beta-site APP-cleaving enzyme 2, Down region aspartic protease, Memapsin-1, Membrane-associated aspartic protease 1
Gene ID 25825
UniProt Q9Y5Z0
Research Area Proteolysis / Ubiquitin, Alzheimer's Disease, Enzymes
Pathways
Application Notes ELISA. Western Blot: BACE2 antibody can be used for detection of BACE2 at 0.5 to 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-beta-Site APP-Cleaving Enzyme 2 (BACE2) (C-Term) antibody (ABIN499397) Immunohistochemistry of BACE2 in rat heart tissue with BACE2 antibody at 2 μg/ml.
Western Blotting (WB) image for anti-beta-Site APP-Cleaving Enzyme 2 (BACE2) (C-Term) antibody (ABIN499397) Western blot analysis of BACE2 in human heart tissue lysate in the absence (A) or pre...
Background publications Hussain, Powell, Howlett et al.: "Identification of a novel aspartic protease (Asp 2) as beta-secretase." in: Molecular and cellular neurosciences, Vol. 14, Issue 6, pp. 419-27, 2000 (PubMed).

Sinha, Anderson, Barbour et al.: "Purification and cloning of amyloid precursor protein beta-secretase from human brain. ..." in: Nature, Vol. 402, Issue 6761, pp. 537-40, 1999 (PubMed).

Yan, Bienkowski, Shuck et al.: "Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity." in: Nature, Vol. 402, Issue 6761, pp. 533-7, 1999 (PubMed).

Vassar, Bennett, Babu-Khan et al.: "Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE." in: Science (New York, N.Y.), Vol. 286, Issue 5440, pp. 735-41, 1999 (PubMed).