BR serine/threonine Kinase 2 (BRSK2) (C-Term) antibody

Details for Product No. ABIN499503
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Antigen
Synonyms BRSK2, C11orf7, PEN11B, SAD1, SADA, STK29, 4833424K13Rik, SAD-A
Epitope
C-Term
(14), (7), (3), (2), (1), (1)
Reactivity
Human, Mouse (Murine)
(40), (31), (17), (14), (13), (12), (12)
Host
Rabbit
(42), (5), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(35), (26), (17), (10), (6), (2), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN499503
401.50 $
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Immunogen BRSK2 antibody was raised against a 23 amino acid peptide from near the carboxy terminus of human BRSK2.
Isotype IgG
Specificity This antibody reacts to BRSK2.
Purification Affinity chromatography purified via peptide column
Alternative Name BRSK2
Background BRSK2 was initially identified through a computer screen of the human genome and shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK2 is expressed in the brain and to a lesser extent in the testes. BRSK2 is a member of the AMP- activated protein kinase subfamily and can be activated by the tumor suppressor kinase LKB1. More recently, it has been shown that both BRSK2 and the related protein BRSK1 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. BRSK2 has also been shown to be an autoantigen in paraneoplastic limbic encephalitis. At least four isoforms of BRSK2 are known to exist.
Alternate names: BR serine/threonine-protein kinase 2, C11orf7, HUSSY-12, PEN11B, SAD-A, STK29, Serine/threonine kinase SAD-A, Serine/threonine-protein kinase 29
Gene ID 9024
UniProt Q8IWQ3
Research Area Neurology, DNA/RNA
Application Notes ELISA. Western Blot: BRSK2 antibody can be used for detection of BRSK2 at 1 – 2 μg/ml. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Manning, Whyte, Martinez et al.: "The protein kinase complement of the human genome." in: Science (New York, N.Y.), Vol. 298, Issue 5600, pp. 1912-34, 2002 (PubMed).

Lizcano, Göransson, Toth et al.: "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1." in: The EMBO journal, Vol. 23, Issue 4, pp. 833-43, 2004 (PubMed).

Kishi, Pan, Crump et al.: "Mammalian SAD kinases are required for neuronal polarization." in: Science (New York, N.Y.), Vol. 307, Issue 5711, pp. 929-32, 2005 (PubMed).

Sabater, Gómez-Choco, Saiz et al.: "BR serine/threonine kinase 2: a new autoantigen in paraneoplastic limbic encephalitis." in: Journal of neuroimmunology, Vol. 170, Issue 1-2, pp. 186-90, 2005 (PubMed).

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