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TBC1 Domain Family, Member 10C (TBC1D10C) (C-Term) antibody

Details for Product No. ABIN499529
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Antigen
Synonyms CARABIN, EPI64C, 1810062O14Rik, AI428527, RGD1311490
Epitope
C-Term
(15), (10), (2), (1)
Reactivity
Human, Mouse (Murine)
(33), (19), (4), (3), (2), (1)
Host
Rabbit
(33), (4)
Clonality
Polyclonal
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(36), (22), (16), (5)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN499529
401.50 $
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Immunogen Carabin antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human Carabin. (AP30181CP-N)
Isotype IgG
Specificity This antibody reacts to Carabin.
Purification Affinity chromatography purified via peptide column
Alternative Name Carabin
Background Antigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.
Alternate names: TBC1 domain family member 10C, TBC1D10C
Gene ID 374403
NCBI Accession NP_940919
UniProt Q8IV04
Application Notes ELISA. Western Blot: Carabin antibody can be used for detection of Carabin at 1 – 2 μg/ml. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications White, Pasztor, Richardson et al.: "The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4." in: Cytogenetics and cell genetics, Vol. 89, Issue 3-4, pp. 272-5, 2000 (PubMed).

Im, Rao: "Activation and deactivation of gene expression by Ca2+/calcineurin-NFAT-mediated signaling." in: Molecules and cells, Vol. 18, Issue 1, pp. 1-9, 2004 (PubMed).

Weil, Israël: "Deciphering the pathway from the TCR to NF-kappaB." in: Cell death and differentiation, Vol. 13, Issue 5, pp. 826-33, 2006 (PubMed).

Pan, Sun, Kardian et al.: "Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin." in: Nature, Vol. 445, Issue 7126, pp. 433-6, 2007 (PubMed).

Validation Images
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