Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) (C-Term) antibody

Details for Product No. ABIN499545
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Antigen
Synonyms MCH4, ALPS2, FLICE2, xCaspase-10, alps2, caspace-10, caspase-10, flice2, mch4, xCaspace-10
Epitope
C-Term
(23), (4), (4), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(112), (16), (15), (1), (1), (1)
Host
Rabbit
(101), (8), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(89), (42), (23), (21), (19), (10), (10), (6), (4), (2), (1), (1)
Pubmed 4 references available
Catalog no. ABIN499545
Quantity 0.1 mg
Price
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Immunogen Human Caspase-10 (C-Terminus) Peptide (AP30189CP-N)
Isotype IgG
Specificity Caspase-10 antibody was raised against a peptide corresponding to amino acids 505 to 521 of human FLICE2. Antibody only recognizes FLICE2 form of caspase-10.
Purification DEAE
Alternative Name Caspase-10
Background Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel ICE/CED-3 protease was identified recently, designated FLICE2 and Mch41,2 and renamed as caspase-10. Caspase-10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase-10 is therefore involved in the CD95 and TNFR1 induced apoptosis1. Caspase-10 cleaves and activates caspase-3, -4, -6, -7, -8 and -9, which causes the proteolytic cleavage of many key proteins such as PARP. Cleavage of PARP occurs in many different systems during apoptosis and is the hallmark of programmed cell death. Caspase-10 is expressed in many tissues and cell lines.
Alternate names: Apoptotic protease Mch-4, CASP-10, CASP10, FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE2, ICE-like apoptotic protease 4, MCH4
Gene ID 843
NCBI Accession AAD28402
UniProt Q92851
Research Area Apoptosis/Necrosis
Application Notes ELISA. Western Blot: Caspase-10 antibody can be used for detection of caspase-10 at 1/500 to1/1000 dilution. A 59 kDa band can be detected. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Chavrier, Vingron, Sander et al.: "Molecular cloning of YPT1/SEC4-related cDNAs from an epithelial cell line." in: Molecular and cellular biology, Vol. 10, Issue 12, pp. 6578-85, 1991 (PubMed).

Fernandes-Alnemri, Armstrong, Krebs et al.: "In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 15, pp. 7464-9, 1996 (PubMed).

Vincenz, Dixit: "Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling." in: The Journal of biological chemistry, Vol. 272, Issue 10, pp. 6578-83, 1997 (PubMed).

Cohen: "Caspases: the executioners of apoptosis." in: The Biochemical journal, Vol. 326 ( Pt 1), Issue 5693, pp. 1-16, 1997 (PubMed).

Hosts (101), (8), (2), (1)
Reactivities (112), (16), (15), (1), (1), (1)
Applications (89), (42), (23), (21), (19), (10), (10), (6), (4), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (23), (4), (4), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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