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CXCR4 antibody (Chemokine (C-X-C Motif) Receptor 4) (N-Term)

Details for Product anti-CXCR4 Antibody No. ABIN499696, Supplier: Log in to see
Antigen
  • CXC-R4
  • CXCR-4
  • cd184
  • d2s201e
  • fb22
  • hm89
  • hsy3rr
  • lap3
  • lcr1
  • lestr
  • npy3r
  • npyr
  • npyrl
  • npyy3r
  • whim
  • xcxcr4
  • cxcr4
  • CD184
  • Cmkar4
  • LESTR
  • PB-CKR
  • PBSF/SDF-1
  • Sdf1r
  • D2S201E
  • FB22
  • HM89
  • HSY3RR
  • LAP3
  • LCR1
  • NPY3R
  • NPYR
  • NPYRL
  • NPYY3R
  • WHIM
  • CXC-R4-B
  • CXCR-4-B
  • CXCR4
  • cb403
  • zgc:109863
Epitope
N-Term
87
15
14
14
13
12
12
11
9
6
5
5
5
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
294
133
70
13
5
4
4
4
3
2
2
2
2
1
1
1
Host
Rabbit
211
75
34
28
2
Clonality
Polyclonal
Conjugate
This CXCR4 antibody is un-conjugated
15
9
7
6
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
211
115
96
67
65
38
30
20
13
13
9
7
7
6
3
2
2
2
2
2
1
1
Supplier
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Immunogen Human CXCR4 (N-Terminus) Peptide
Isotype IgG
Specificity CXCR4 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human CXCR4.
Purification DEAE
Alternative Name CD184 / CXCR4 (CXCR4 Antibody Abstract)
Background Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites.Synonyms: C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, FB22, Fusin, HM89, LCR1, LESTR, Leukocyte-derived seven transmembrane domain receptor, NPYRL, SDF1 receptor, Stromal cell-derived factor 1 receptor
Gene ID 7852
NCBI Accession NP_003458
UniProt P61073
Research Area CD Antigens, Surface Receptors of Immune Cells, Chemokines, Receptors
Pathways
Application Notes ELISA. Western Blot: 1 - 2 μg/mL. Immunocytochemistry: 10 μg/mL. Immunoprecipitation: 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunofluorescence (IF) image for anti-CXCR4 antibody (Chemokine (C-X-C Motif) Receptor 4) (N-Term) (ABIN499696) Immunocytochemistry of CXCR4 in HeLa cells with AP30266PU-N CXCR4 antibody at 2 μg/ml.
Western Blotting (WB) image for anti-CXCR4 antibody (Chemokine (C-X-C Motif) Receptor 4) (N-Term) (ABIN499696) Western blot analysis of CXCR4 in HeLa whole cell lysate with AP30266PU-N CXCR4 antib...
Background publications Dimitrov: "How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity." in: Cell, Vol. 91, Issue 6, pp. 721-30, 1998 (PubMed).

Berson, Long, Doranz et al.: "A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains." in: Journal of virology, Vol. 70, Issue 9, pp. 6288-95, 1996 (PubMed).

Doranz, Rucker, Yi et al.: "A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors." in: Cell, Vol. 85, Issue 7, pp. 1149-58, 1996 (PubMed).

Feng, Broder, Kennedy et al.: "HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor." in: Science (New York, N.Y.), Vol. 272, Issue 5263, pp. 872-7, 1996 (PubMed).