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DARC antibody (C-Term)

This anti-DARC antibody is a Rabbit Polyclonal antibody detecting DARC in WB, IHC (p) and EIA. Suitable for Human, Mouse and Rat.
Catalog No. ABIN499710

Quick Overview for DARC antibody (C-Term) (ABIN499710)

Target

See all DARC Antibodies
DARC (Duffy Blood Group, Chemokine Receptor (DARC))

Reactivity

Human, Mouse, Rat

Host

  • 33
  • 10
  • 2
  • 2
Rabbit

Clonality

  • 34
  • 12
  • 1
Polyclonal

Conjugate

  • 33
  • 4
  • 3
  • 3
  • 2
  • 2
This DARC antibody is un-conjugated

Application

  • 30
  • 25
  • 14
  • 9
  • 9
  • 7
  • 6
  • 5
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
  • Binding Specificity

    • 9
    • 8
    • 7
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term

    Specificity

    This antibody reacts to DARC.

    Purification

    Affinity chromatography purified via peptide column

    Immunogen

    DARC antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human DARC.

    Isotype

    IgG
  • Application Notes

    ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Restrictions

    For Research Use only
  • Buffer

    PBS containing 0.02 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C

    Storage Comment

    Store the antibody undiluted at 2-8 °C.
  • Target

    DARC (Duffy Blood Group, Chemokine Receptor (DARC))

    Alternative Name

    CD234 / DARC

    Background

    DARC, also known as the Duffy antigen/chemokine receptor, is a seven-transmembrane protein homologous to the classical chemokine G-protein coupled receptors (GPCRs) with the exception of the motif required for G protein coupling. DARC can bind with high affinity several chemokines without transducing any signal, suggesting it may modulate the signals normally induced by these chemokines. Recently, DARC was found to interact with KAI1, a four transmembrane protein recently identified as a tumor metastasis suppressor protein. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least three isoforms of DARC are known to exist.Synonyms: Duffy antigen/chemokine receptor, FY, Fy glycoprotein, GPD, Glycoprotein D, GpFy, Plasmodium vivax receptor

    Gene ID

    2532

    UniProt

    Q16570
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