TNFRSF21 antibody (AA 42-56)

Catalog No. ABIN499766

Product Details anti-TNFRSF21 Antibody

Target: TNFRSF21 (Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21))

Binding Specificity: AA 42-56

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFRSF21 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: DR6 antibody was raised against a peptide corresponding to amino acids 42 to 56 of human DR6 precursor.

Purification: DEAE

Immunogen: DR6 antibody was raised against a peptide corresponding to amino acids 42 to 56 of human DR6 precursor.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 1/500 to 1/2000. An approximately 68 kDa band can be detected.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for TNFRSF21

Target: TNFRSF21 (Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21))

Alternative Name: TNFRSF21 / Death Receptor 6 (DR6) (TNFRSF21 Products)

Synonyms: TNFRSF21 antibody, tnfrsf21 antibody, MGC146356 antibody, BM-018 antibody, CD358 antibody, DR6 antibody, AA959878 antibody, R74815 antibody, TR7 antibody, dr6 antibody, im:6795346 antibody, wu:fa55e01 antibody, wu:fb02e11 antibody, wu:fc29a09 antibody, wu:fi27h08 antibody, TNF receptor superfamily member 21 antibody, tumor necrosis factor receptor superfamily member 21 antibody, tumor necrosis factor receptor superfamily, member 21 antibody, TNFRSF21 antibody, tnfrsf21 antibody, Tnfrsf21 antibody

Background: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6 (1). Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappaB and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.Synonyms: Tumor necrosis factor receptor superfamily member 21

Gene ID: 27242

UniProt: O75509

Pathways: Regulation of Lipid Metabolism by PPARalpha