GDNF Family Receptor alpha 2 (GFRA2) (Middle Region) antibody

Details for Product No. ABIN499885
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Antigen
Synonyms NTNRA, RETL2, TRNR2, GDNFRB, NRTNR-ALPHA, Retl2, NTNRALPHA, DKFZP459C0228, GFRA2, ntnra, retl2, trnr2, gdnfrb, nrtnr-alpha, gfra2
Epitope
Middle Region
(4), (4), (3), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(47), (30), (30), (13), (13), (12)
Host
Rabbit
(44), (2), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(39), (15), (10), (9), (3), (2), (2), (2), (1)
Pubmed 4 references available
Catalog no. ABIN499885
Quantity 0.1 mg
Price
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Immunogen Human GFR alpha 2 Peptide (AP30362CP-N)
Isotype IgG
Specificity GFR alpha 2 antibody was raised against a peptide corresponding to amino acids 377 to 391 of human GFR alpha 2.
Purification DEAE
Alternative Name GFRA2 / GDNFR-beta
Background Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRalpha, which is a cell surface receptor for NTN. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently. NTNRalpha was also termed GDNFRbeta, Ret ligand 2 (RETL2) or TGFbeta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRalpha-2 recently. GFRalpha-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRalpha-2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.
Alternate names: GDNF family receptor alpha-2, GDNF receptor beta, GDNFRB, GFR-alpha-2, Neurturin receptor alpha, RET ligand 2, RETL2, TGF-beta-related neurotrophic factor receptor 2, TRNR2
Gene ID 2675
NCBI Accession AAC52036
UniProt O00451
Application Notes ELISA. Western Blot: 1/1000 to 1/2000. A 52 kDa band should be detected. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Kotzbauer, Lampe, Heuckeroth et al.: "Neurturin, a relative of glial-cell-line-derived neurotrophic factor." in: Nature, Vol. 384, Issue 6608, pp. 467-70, 1997 (PubMed).

Baloh, Tansey, Golden et al.: "TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret." in: Neuron, Vol. 18, Issue 5, pp. 793-802, 1997 (PubMed).

Klein, Sherman, Ho et al.: "A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor." in: Nature, Vol. 387, Issue 6634, pp. 717-21, 1997 (PubMed).

Buj-Bello, Adu, Piñón et al.: "Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase." in: Nature, Vol. 387, Issue 6634, pp. 721-4, 1997 (PubMed).

Hosts (44), (2), (1), (1)
Reactivities (47), (30), (30), (13), (13), (12)
Applications (39), (15), (10), (9), (3), (2), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (4), (3), (1), (1), (1), (1)
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