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Details for Product No. ABIN499890

Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18) antibody

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Antigen
Synonyms AITRL, GITRL, TL6, hGITRL, Gitrl
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN499890
Quantity 0.1 mg
Price
390.50 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 6 to 8 Business Days
Immunogen Recombinant human GITR ligand (AP30365CP-N)
Isotype IgG
Specificity GITRL antibody was raised against purified recombinant human GITR ligand.
Purification Affinity chromatography purified via peptide column
Alternative Name TNFSF18 / AITRL
Background The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kappaB and various mitogen- activated protein kinases (reviewed in 1). The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions (2,3). Its ligand GITRL is expressed in endothelial and antigen-presenting cells (4) and can activate NF- kappaB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR (5). Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF- kappaB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2 (4).
Alternate names: AITRL, Activation-inducible TNF-related ligand, GITRL, Glucocorticoid-induced TNF-related ligand, TL6, Tumor necrosis factor ligand superfamily member 18, hGITRL
Gene ID 8995
NCBI Accession Q9UNG2
UniProt Q9UNG2
Application Notes ELISA. Western Blot: 1 μg/ml. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Gurney, Marsters, Huang et al.: "Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR." in: Current biology : CB, Vol. 9, Issue 4, pp. 215-8, 1999 (PubMed).

Shimizu, Yamazaki, Takahashi et al.: "Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance." in: Nature immunology, Vol. 3, Issue 2, pp. 135-42, 2002 (PubMed).

Ronchetti, Nocentini, Riccardi et al.: "Role of GITR in activation response of T lymphocytes." in: Blood, Vol. 100, Issue 1, pp. 350-2, 2002 (PubMed).

Gaur, Aggarwal: "Regulation of proliferation, survival and apoptosis by members of the TNF superfamily." in: Biochemical pharmacology, Vol. 66, Issue 8, pp. 1403-8, 2003 (PubMed).

Alternatives for antigen "Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18)", type "Antibodies"
Hosts (53), (29), (6)
Reactivities (55), (53), (17), (1)
Applications (49), (43), (39), (10), (8), (3), (3), (2), (2), (1), (1)
Conjugates (8), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (2), (2), (2), (2), (2), (1), (1), (1)
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