Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18) antibody

Details for Product No. ABIN499890
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Antigen
Synonyms AITRL, GITRL, TL6, hGITRL, Gitrl
Reactivity
Human, Mouse (Murine)
(57), (47), (13), (1)
Host
Rabbit
(54), (24), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (5), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
(53), (39), (38), (10), (8), (5), (4), (4), (3), (3), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN499890
401.50 $
Plus shipping costs $45.00

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  • +1 404 474 4654
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Immunogen Recombinant human GITR ligand
Isotype IgG
Specificity GITRL antibody was raised against purified recombinant human GITR ligand.
Purification Affinity chromatography purified via peptide column
Alternative Name TNFSF18 / AITRL
Background The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kappaB and various mitogen-activated protein kinases (reviewed in 1). The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions (2,3). Its ligand GITRL is expressed in endothelial and antigen-presenting cells (4) and can activate NF-kappaB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR (5). Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-kappaB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2 (4).Synonyms: AITRL, Activation-inducible TNF-related ligand, GITRL, Glucocorticoid-induced TNF-related ligand, TL6, Tumor necrosis factor ligand superfamily member 18, hGITRL
Gene ID 8995
UniProt Q9UNG2
Application Notes ELISA. Western Blot: 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Gurney, Marsters, Huang et al.: "Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR." in: Current biology : CB, Vol. 9, Issue 4, pp. 215-8, 1999 (PubMed).

Shimizu, Yamazaki, Takahashi et al.: "Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance." in: Nature immunology, Vol. 3, Issue 2, pp. 135-42, 2002 (PubMed).

Ronchetti, Nocentini, Riccardi et al.: "Role of GITR in activation response of T lymphocytes." in: Blood, Vol. 100, Issue 1, pp. 350-2, 2002 (PubMed).

Gaur, Aggarwal: "Regulation of proliferation, survival and apoptosis by members of the TNF superfamily." in: Biochemical pharmacology, Vol. 66, Issue 8, pp. 1403-8, 2003 (PubMed).

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