Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18) antibody

Details for Product No. ABIN499890
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Synonyms AITRL, GITRL, TL6, hGITRL, Gitrl
Human, Mouse (Murine)
(97), (86), (12), (1)
(83), (60), (23)
(15), (9), (7), (6), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
(91), (86), (59), (10), (7), (7), (5), (5), (3), (3), (2), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Recombinant human GITR ligand
Isotype IgG
Specificity GITRL antibody was raised against purified recombinant human GITR ligand.
Purification Affinity chromatography purified via peptide column
Alternative Name TNFSF18 / AITRL (TNFSF18 Antibody Abstract)
Background The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kappaB and various mitogen-activated protein kinases (reviewed in 1). The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions (2,3). Its ligand GITRL is expressed in endothelial and antigen-presenting cells (4) and can activate NF-kappaB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR (5). Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-kappaB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2 (4).Synonyms: AITRL, Activation-inducible TNF-related ligand, GITRL, Glucocorticoid-induced TNF-related ligand, TL6, Tumor necrosis factor ligand superfamily member 18, hGITRL
Gene ID 8995
UniProt Q9UNG2
Application Notes ELISA. Western Blot: 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunofluorescence (IF) image for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18) antibody (ABIN499890) Immunocytochemistry of GITRL in THP-1 cells with AP30365PU-N GITRL antibody at 10 μg/ml.
Western Blotting (WB) image for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18) antibody (ABIN499890) Western blot analysis of (A) 5 ng, (B) 25 ng, and (C) 50 ng of purified recombinant G...
Background publications Gaur, Aggarwal: "Regulation of proliferation, survival and apoptosis by members of the TNF superfamily." in: Biochemical pharmacology, Vol. 66, Issue 8, pp. 1403-8, 2003 (PubMed).

Ronchetti, Nocentini, Riccardi et al.: "Role of GITR in activation response of T lymphocytes." in: Blood, Vol. 100, Issue 1, pp. 350-2, 2002 (PubMed).

Shimizu, Yamazaki, Takahashi et al.: "Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance." in: Nature immunology, Vol. 3, Issue 2, pp. 135-42, 2002 (PubMed).

Gurney, Marsters, Huang et al.: "Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR." in: Current biology : CB, Vol. 9, Issue 4, pp. 215-8, 1999 (PubMed).

Catalog No. ABIN499890
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