TNFSF18 antibody (AA 72-199)

Catalog No. ABIN7173812

Product Details anti-TNFSF18 Antibody

Target: TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))

Binding Specificity: AA 72-199

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFSF18 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Tumor necrosis factor ligand superfamily member 18 protein (72-199AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TNFSF18

Target: TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))

Alternative Name: TNFSF18 (TNFSF18 Products)

Synonyms: Gitrl antibody, AITRL antibody, GITRL antibody, TL6 antibody, hGITRL antibody, TNLG2A antibody, tumor necrosis factor (ligand) superfamily, member 18 antibody, TNF superfamily member 18 antibody, Tnfsf18 antibody, TNFSF18 antibody

Background:

Background: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation.

Aliases: Activation inducible TNF related ligand antibody, Activation-inducible TNF-related ligand antibody, AITR ligand antibody, AITRL antibody, GITR ligand antibody, GITRL antibody, Glucocorticoid induced TNF related ligand antibody, Glucocorticoid induced TNFR related protein ligand antibody, Glucocorticoid-induced TNF-related ligand antibody, hGITRL antibody, MGC138237 antibody, TL6 antibody, TNF18_HUMAN antibody, TNFSF18 antibody, TNLG2A antibody, Tumor necrosis factor (ligand) superfamily member 18 antibody, Tumor necrosis factor ligand 2A antibody, Tumor necrosis factor ligand superfamily member 18 antibody

UniProt: Q9UNG2