Glycoprotein VI (Platelet) (GP6) (C-Term) antibody

Details for Product No. ABIN499916
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Synonyms 9830166G18Rik, Gm469, Gpvi, BDPLT11, GPIV, GPVI
(22), (9), (5), (3), (3), (3), (1)
Human, Mouse (Murine), Rat (Rattus)
(64), (23), (23)
(6), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(55), (32), (17), (15), (10), (8), (5), (5), (2), (2), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN499916
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Immunogen GPVI antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human GPVI.
Isotype IgG
Specificity This antibody reacts to GPVI.
Purification Affinity chromatography purified via peptide column
Alternative Name Platelet Glycoprotein VI
Background Glycoprotein VI (GP6) is a 58kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. It is uniquely expressed by cells of the megakaryocytic/platelet lineage, and is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcR) and natural killer receptors. Glycoprotein VI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. GPVI deficiency can result in bleeding disorders. Further study should reveal the extent of GPVI involvement in thrombotic disease and allow the development of alternative anti-thrombotic compounds.Synonyms: GP6, GPVI, Glycoprotein 6
Gene ID 51206
NCBI Accession NP_057447
UniProt Q9HCN6
Application Notes ELISA. Western Blot: 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Inoue, Suzuki-Inoue, Dean et al.: "Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2." in: The Journal of cell biology, Vol. 160, Issue 5, pp. 769-80, 2003 (PubMed).

Jarvis, Atkinson, Snell et al.: "Distinct roles of GPVI and integrin alpha(2)beta(1) in platelet shape change and aggregation induced by different collagens." in: British journal of pharmacology, Vol. 137, Issue 1, pp. 107-17, 2002 (PubMed).

Jandrot-Perrus, Busfield, Lagrue et al.: "Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily." in: Blood, Vol. 96, Issue 5, pp. 1798-807, 2000 (PubMed).

Clemetson, Polgar, Magnenat et al.: "The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors." in: The Journal of biological chemistry, Vol. 274, Issue 41, pp. 29019-24, 1999 (PubMed).

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