GRIK4 antibody (C-Term)

Catalog No. ABIN499928

The Rabbit Polyclonal anti-GRIK4 antibody is suitable to detect GRIK4 in samples from Human, Rat and Mouse. It has been validated for WB, IHC (p) and EIA.

Quick Overview for GRIK4 antibody (C-Term) (ABIN499928)

Target: GRIK4 (Glutamate Receptor, Ionotropic, Kainate 4 (GRIK4))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIK4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-GRIK4 Antibody

Binding Specificity: C-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: Grik4 antibody was raised against a 19 amino acid peptide near the carboxy terminus of the human Grik4.

Isotype: IgG

Application Details

Application Notes: ELISA. Western Blot: 0.5 - 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Target Details for GRIK4

Target: GRIK4 (Glutamate Receptor, Ionotropic, Kainate 4 (GRIK4))

Alternative Name: Glutamate Receptor KA1 / GRIK4

Background: Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder. Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE.Synonyms: EAA1, Excitatory amino acid receptor 1, Glutamate receptor ionotropic kainate 4

Gene ID: 2900

UniProt: Q16099

Pathways: Synaptic Membrane