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Details for Product No. ABIN499998

interleukin 23, alpha subunit p19 (IL23A) (N-Term) antibody

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Antigen
Synonyms p19, IL-23, IL-23A, IL23P19, P19, SGRF, IL23, il23p19
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN499998
Quantity 0.1 mg
Price
390.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen IL-23 antibody was raised against a 16 amino acid peptide from near the amino terminus of human IL-23. (AP30419CP-N)
Isotype IgG
Specificity This antibody reacts to Il-23.
Purification Affinity chromatography purified via peptide column
Alternative Name Interleukin-23 alpha / IL23A
Background Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes (3,4). Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-alpha from activated T cells, and can stimulate macrophages to produce TNF-alpha and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.
Alternate names: IL-23 subunit alpha, IL-23p19, Interleukin-23 subunit p19, SGRF
Gene ID 51561
NCBI Accession AAH66268
UniProt Q9NPF7
Application Notes ELISA. Western Blot: 1 - 2 μg/ml. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Storage 4 °C
Expiry Date 12 months
Background publications Hunter: "New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions." in: Nature reviews. Immunology, Vol. 5, Issue 7, pp. 521-31, 2005 (PubMed).

Alternatives for antigen "interleukin 23, alpha subunit p19 (IL23A)", type "Antibodies"
Hosts (58), (20), (9)
Reactivities (74), (42), (13)
Applications (60), (35), (19), (10), (10), (8), (6), (4), (4), (3), (2), (2), (2), (2), (1)
Conjugates (5), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (15), (13), (4)
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