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interleukin 23, alpha subunit p19 (IL23A) (N-Term) antibody

Details for Product No. ABIN499998, Supplier: Login to see
Antigen
  • IL-23
  • IL-23A
  • IL23P19
  • P19
  • SGRF
  • p19
  • IL23
  • il23p19
  • FIL1
  • FIL1(ZETA)
  • FIL1Z
  • IL-1F7
  • IL-1H
  • IL-1H4
  • IL-1RP1
  • IL-37
  • IL1F7
  • IL1H4
  • IL1RP1
Epitope
N-Term
13
9
8
5
1
1
1
Reactivity
Human, Mouse (Murine)
65
21
1
Host
Rabbit
39
20
15
1
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
60
22
12
9
6
5
5
5
4
3
2
2
1
1
1
1
1
1
Supplier
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Immunogen IL-23 antibody was raised against a 16 amino acid peptide from near the amino terminus of human IL-23.
Isotype IgG
Specificity This antibody reacts to Il-23.
Purification Affinity chromatography purified via peptide column
Alternative Name Interleukin-23 alpha / IL23A (IL23A Antibody Abstract)
Background Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes (3,4). Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-alpha from activated T cells, and can stimulate macrophages to produce TNF-alpha and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.Synonyms: IL-23 subunit alpha, IL-23p19, Interleukin-23 subunit p19, SGRF
Gene ID 51561
UniProt Q9NPF7
Pathways
Application Notes ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-interleukin 23, alpha subunit p19 (IL23A) (N-Term) antibody (ABIN499998) Immunohistochemistry of IL-23 in mouse pancreas tissue with IL-23 antibody at 2 μg/ml.
Western Blotting (WB) image for anti-interleukin 23, alpha subunit p19 (IL23A) (N-Term) antibody (ABIN499998) Western blot analysis of IL-23 in mouse pancreas tissue lysate with AP30419PU-N IL-23...
Background publications Hunter: "New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions." in: Nature reviews. Immunology, Vol. 5, Issue 7, pp. 521-31, 2005 (PubMed).