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IRAK3 antibody

IRAK3 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500046
  • Target See all IRAK3 Antibodies
    IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))
    Reactivity
    • 58
    • 35
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 79
    • 7
    • 1
    Rabbit
    Clonality
    • 72
    • 15
    Polyclonal
    Conjugate
    • 39
    • 7
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    This IRAK3 antibody is un-conjugated
    Application
    • 72
    • 39
    • 13
    • 13
    • 10
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    IRAK-M antibody was raised against a peptide corresponding to amino acids from the carboxy terminus of human IRAK-M. IRAK-M antibody has no cross response to IRAK or IRAK2.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    Human IRAK-M Peptide
    Isotype
    IgG
    Top Product
    Discover our top product IRAK3 Primary Antibody
  • Application Notes
    ELISA. Western Blot: 0.5 to 1 μg/mL. A 68 kDa major band can be detected. Immunohistochemistry: 2 μg/mL. .
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))
    Alternative Name
    IRAK3 (IRAK3 Products)
    Synonyms
    IRAK3 antibody, si:dkey-150i15.2 antibody, ASRT5 antibody, IRAKM antibody, IrakM antibody, 4833428C18Rik antibody, AI563835 antibody, IRAK-M antibody, interleukin 1 receptor associated kinase 3 antibody, interleukin-1 receptor-associated kinase 3 antibody, IRAK3 antibody, irak3 antibody, Irak3 antibody
    Background
    Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-betaB by IL-1/Toll receptors (1,2), which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M (3). IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-betaB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.Synonyms: IL-1 receptor-associated kinase M, IRAK-3, IRAK-M, Interleukin-1 receptor-associated kinase 3
    Gene ID
    11213
    UniProt
    Q9Y616
    Pathways
    TLR Signaling, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades
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