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Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) antibody

Details for Product No. ABIN500046, Supplier: Login to see
Antigen
  • IRAK3
  • si:dkey-150i15.2
  • ASRT5
  • IRAKM
  • IrakM
  • 4833428C18Rik
  • AI563835
  • IRAK-M
Alternatives
anti-Human Interleukin-1 Receptor-Associated Kinase 3 antibody for Western Blotting
Reactivity
Human, Mouse (Murine), Rat (Rattus)
106
50
30
1
Host
Rabbit
116
17
13
Clonality
Polyclonal
Conjugate
Un-conjugated
6
6
5
5
5
5
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
135
81
34
18
12
8
3
2
2
1
1
1
1
1
1
Supplier
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Immunogen Human IRAK-M Peptide
Isotype IgG
Specificity IRAK-M antibody was raised against a peptide corresponding to amino acids from the carboxy terminus of human IRAK-M. IRAK-M antibody has no cross response to IRAK or IRAK2.
Purification Affinity chromatography purified via peptide column
Alternative Name IRAK3 (IRAK3 Antibody Abstract)
Background Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-betaB by IL-1/Toll receptors (1,2), which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M (3). IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-betaB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.Synonyms: IL-1 receptor-associated kinase M, IRAK-3, IRAK-M, Interleukin-1 receptor-associated kinase 3
Gene ID 11213
UniProt Q9Y616
Pathways TLR Signaling
Application Notes ELISA. Western Blot: 0.5 to 1 μg/mL. A 68 kDa major band can be detected. Immunohistochemistry: 2 μg/mL. .
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) antibody (ABIN500046) Immunohistochemical staining of rat liver cells using AP30443PU-N IRAK-M antibody at ...
Western Blotting (WB) image for anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) antibody (ABIN500046) Western blot analysis of IRAK-M in mouse spleen (M) and rat liver (R) tissue lysates ...
Background publications Cao, Henzel, Gao: "IRAK: a kinase associated with the interleukin-1 receptor." in: Science (New York, N.Y.), Vol. 271, Issue 5252, pp. 1128-31, 1996 (PubMed).