DLGAP1 antibody (Center)

Catalog No. ABIN500652

Product Details anti-DLGAP1 Antibody

Target: DLGAP1 (Discs, Large (Drosophila) Homolog-Associated Protein 1 (DLGAP1))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLGAP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects SAPAP1. It will not cross-react with other SAPAP proteins.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogen: SAPAP1 antibody was raised against a 18 amino acid peptide from near the center of human SAPAP1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for DLGAP1

Target: DLGAP1 (Discs, Large (Drosophila) Homolog-Associated Protein 1 (DLGAP1))

Alternative Name: DLGAP1 / SAPAP1 (DLGAP1 Products)

Synonyms: DKFZp469D0713 antibody, gkap antibody, sapap1 antibody, DAP-1 antibody, DAP-1-ALPHA antibody, DAP-1-BETA antibody, GKAP antibody, SAPAP1 antibody, hGKAP antibody, 4933422O14Rik antibody, 9630002F18 antibody, AI845682 antibody, AI848168 antibody, BB075781 antibody, D17Bwg0511e antibody, GKAP/SAPAP antibody, GKPA/SAPAP antibody, Gkap antibody, Sapap1 antibody, mKIAA4162 antibody, DLG associated protein 1 antibody, discs, large (Drosophila) homolog-associated protein 1 antibody, disks large-associated protein 1 antibody, discs, large homolog-associated protein 1 antibody, discs, large (Drosophila) homolog-associated protein 1b antibody, DLGAP1 antibody, LOC100408093 antibody, LOC100548434 antibody, dlgap1 antibody, Dlgap1 antibody, dlgap1b antibody

Background: SAP90/PSD-95-associated protein 1 (SAPAP1, also known as DLGAP1 or GKAP) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP1 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). SAPAP1 mRNA is targeted to cell bodies in a similar manner to SAPAP2 and -4, whereas SAPAP3 mRNA is detected mainly in cell bodies. SAPAP1 protein however, is targeted to the synapse and is not reliant on the synaptic localization of PSD-95 or the synaptic scaffolding molecule (S-SCAM). At least three isoforms of SAPAP1 are known to exist.Synonyms: DAP-1, DAP1, Disks large-associated protein 1, GKAP, Guanylate kinase-associated protein, PSD-95/SAP90-binding protein 1, SAP90/PSD-95-associated protein 1

Gene ID: 9229

NCBI Accession: NP_001003809

UniProt: O14490