SCO2 antibody (C-Term)

Catalog No. ABIN500688

Product Details anti-SCO2 Antibody

Target: SCO2 (SCO2 Cytochrome C Oxidase Assembly Protein (SCO2))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCO2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects SCO2.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatography

Immunogen: SCO2 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human SCO2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for SCO2

Target: SCO2 (SCO2 Cytochrome C Oxidase Assembly Protein (SCO2))

Alternative Name: SCO2 (SCO2 Products)

Synonyms: CEMCOX1 antibody, MYP6 antibody, SCO1L antibody, SCO cytochrome oxidase deficient homolog 2 (yeast) antibody, SCO2 cytochrome c oxidase assembly protein antibody, SCO2, cytochrome c oxidase assembly protein antibody, SCO2 antibody, Sco2 antibody

Background: Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding. Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cells lines, the drop in SCO2 expression leads to a shift from normal aerobic respiration towards the production of glycolytic ATP. Defects in the SCO2 protein are also associated with fatal infantile cardioencephalomyopathy and COX deficiency.Synonyms: Synthesis of cytochrome c oxidase 2, cytochrome oxidase deficient homolog 2

Gene ID: 3184203

UniProt: O43819, Q5KW01

Pathways: Transition Metal Ion Homeostasis, Warburg Effect