Stromal Interaction Molecule 1 (STIM1) (C-Term) antibody

Details for Product No. ABIN500827
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Antigen
Synonyms stim1, MGC76045, STIM1, si:dkey-24p1.5, MGC154748, si:ch211-112l17.2, Stim1, D11S4896E, GOK, TAM, SIM
Epitope
C-Term
(27), (9), (8), (6), (4), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(88), (46), (46), (25), (24), (18), (17), (2)
Host
Rabbit
(65), (23), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(73), (35), (26), (24), (14), (12), (12), (8), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN500827
401.50 $
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Immunogen STIM1 antibody was raised against a 24 amino acid peptide from near the carboxy terminus of human STIM1.
Isotype IgG
Specificity This antibody detects STIM1 / GOK. It is predicted to have no cross-reactivity to STIM2.
Purification Peptide affinity chromatography
Alternative Name STIM1 / GOK
Background In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites which act as the Ca++ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca++ entry. At least two isoforms of STIM1 are known to exist, this antibody will detect only the larger form.
Alternate names: Stromal interaction molecule 1
Gene ID 6786
NCBI Accession NP_003147
Application Notes ELISA. Western blot: 1 – 2 μg/ml. Immunohisochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1,0 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Zhang, Yu, Roos et al.: "STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane." in: Nature, Vol. 437, Issue 7060, pp. 902-5, 2005 (PubMed).

Spassova, Soboloff, He et al.: "STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 11, pp. 4040-5, 2006 (PubMed).

Feske, Gwack, Prakriya et al.: "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function." in: Nature, Vol. 441, Issue 7090, pp. 179-85, 2006 (PubMed).

Luik, Lewis: "New insights into the molecular mechanisms of store-operated Ca2+ signaling in T cells." in: Trends in molecular medicine, Vol. 13, Issue 3, pp. 103-7, 2007 (PubMed).

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