Did you know that you can buy products from over 140 different suppliers from us?

ADAM Metallopeptidase Domain 17 (ADAM17) (C-Term) antibody

Details for Product No. ABIN500861
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms ADAM18, CD156B, CSVP, NISBD, TACE, Tace, CD156b, adam17, si:dkey-81b15.2, adam18, cd156b, csvp, tace
Epitope
C-Term
(43), (21), (9), (7), (6), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(164), (73), (68), (30), (30), (18), (2)
Host
Rabbit
(149), (12), (9), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(136), (86), (30), (26), (24), (20), (14), (10), (8), (5), (2), (1), (1), (1)
Pubmed 6 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN500861
401.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen A peptide corresponding to amino acids near the carboxy terminus of Human CD156b / ADAM17
Isotype IgG
Specificity This antibody detects CD156b / ADAM17 at C-term. 80 to 130 kDa bands can be detected, which may represent mature protein, precursor, and glycosylated CD156b.
Purification Immunoaffinity Chromatography
Alternative Name CD156b / ADAM17
Background Tumor-necrosis factor-a is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-alpha is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-alpha. TNF-alpha converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFa, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP) (4,5). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association.
Alternate names: CSVP, Disintegrin and metalloproteinase domain-containing protein 17, Snake venom-like protease, TACE, TNF-alpha convertase, TNF-alpha-converting enzyme
Gene ID 6868
NCBI Accession NP_003174
Research Area CD Antigens, Surface Receptors of Immune Cells, Enzymes
Application Notes ELISA. Western blot: 1: 500 to 1: 2000. Immunoflourescence. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Black, Rauch, Kozlosky et al.: "A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells." in: Nature, Vol. 385, Issue 6618, pp. 729-33, 1997 (PubMed).

Moss, Jin, Milla et al.: "Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha." in: Nature, Vol. 385, Issue 6618, pp. 733-6, 1997 (PubMed).

Giegel, Chaplin: "Targets in cytokine activation." in: Agents and actions. Supplements, Vol. 49, pp. 1-3, 1998 (PubMed).

Buxbaum, Liu, Luo et al.: "Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor." in: The Journal of biological chemistry, Vol. 273, Issue 43, pp. 27765-7, 1998 (PubMed).

Peschon, Slack, Reddy et al.: "An essential role for ectodomain shedding in mammalian development." in: Science (New York, N.Y.), Vol. 282, Issue 5392, pp. 1281-4, 1998 (PubMed).

Mizui, Yamazaki, Sagane et al.: "cDNA cloning of mouse tumor necrosis factor-alpha converting enzyme (TACE) and partial analysis of its promoter." in: Gene, Vol. 233, Issue 1-2, pp. 67-74, 1999 (PubMed).

Hosts (149), (12), (9), (1)
Reactivities (164), (73), (68), (30), (30), (18), (2)
Applications (136), (86), (30), (26), (24), (20), (14), (10), (8), (5), (2), (1), (1), (1)
Conjugates (6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Epitopes (43), (21), (9), (7), (6), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN500861
401.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
back to top