TNF Receptor-Associated Factor 3 (TRAF3) (N-Term) antibody

Details for Product No. ABIN501026
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Antigen
Synonyms CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1, amn, T-BAM, AI528849, LOC100218184
Epitope
N-Term
(12), (8), (3), (2), (2), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(62), (46), (28), (1)
Host
Rabbit
(58), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(54), (26), (13), (10), (10), (8), (4), (2), (2), (2), (2), (2), (1)
Pubmed 3 references available
Catalog no. ABIN501026
Quantity 0.1 mg
Price
401.50 $   Plus shipping costs $45.00
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Immunogen TRAF3 antibody was raised against a 15 amino acid peptide from near the amino terminus of human.
Isotype IgG
Specificity This antibody detects TRAF3 / CRAF1 at N-term.
Purification Peptide affinity chromatography
Alternative Name TRAF3 / CRAF1
Background Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily (1). TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr virus transforming protein LMP1 (2,3). Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF-kappaB (4). Besides CD40, TRAF3 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF2 and the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LTbetaR.
Alternate names: CAP-1, CAP1, CD40 receptor-associated factor 1, CD40-binding protein, CD40BP, LAP1, LMP1-associated protein, TNF receptor-associated factor 3
Gene ID 7187
NCBI Accession NP_663777
Application Notes ELISA. Western blot: 1 - 2 μg/ml. Immunoflourescence. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Cheng, Cleary, Ye et al.: "Involvement of CRAF1, a relative of TRAF, in CD40 signaling." in: Science (New York, N.Y.), Vol. 267, Issue 5203, pp. 1494-8, 1995 (PubMed).

Mosialos, Birkenbach, Yalamanchili et al.: "The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family." in: Cell, Vol. 80, Issue 3, pp. 389-99, 1995 (PubMed).

van Eyndhoven, Gamper, Cho et al.: "TRAF-3 mRNA splice-deletion variants encode isoforms that induce NF-kappaB activation." in: Molecular immunology, Vol. 36, Issue 10, pp. 647-58, 1999 (PubMed).

Hosts (58), (5)
Reactivities (62), (46), (28), (1)
Applications (54), (26), (13), (10), (10), (8), (4), (2), (2), (2), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (8), (3), (2), (2), (1), (1)
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