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TRAF3 antibody (TNF Receptor-Associated Factor 3) (N-Term)

Details for Product anti-TRAF3 Antibody No. ABIN501026, Supplier: Log in to see
Antigen
  • CAP-1
  • CAP1
  • CD40bp
  • CRAF1
  • IIAE5
  • LAP1
  • AI528849
  • T-BAM
  • amn
Alternatives
anti-Human TRAF3 antibody for Western Blotting
Epitope
N-Term
17
13
10
8
3
3
3
2
2
2
2
2
2
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
87
54
38
2
2
Host
Rabbit
80
9
Clonality
Polyclonal
Conjugate
This TRAF3 antibody is un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
73
31
14
11
8
8
8
7
3
2
1
Supplier
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Immunogen TRAF3 antibody was raised against a 15 amino acid peptide from near the amino terminus of human.
Isotype IgG
Specificity This antibody detects TRAF3 / CRAF1 at N-term.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat
Purification Peptide affinity chromatography
Alternative Name TRAF3 / CRAF1 (TRAF3 Antibody Abstract)
Background Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily (1). TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr virus transforming protein LMP1 (2,3). Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF-kappaB (4). Besides CD40, TRAF3 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF2 and the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LTbetaR.Synonyms: CAP-1, CAP1, CD40 receptor-associated factor 1, CD40-binding protein, CD40BP, LAP1, LMP1-associated protein, TNF receptor-associated factor 3
Gene ID 7187
NCBI Accession NP_663777
Pathways NF-kappaB Signaling, Apoptosis, TLR Signaling
Application Notes ELISA. Western blot: 1 - 2 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunofluorescence (IF) image for anti-TRAF3 antibody (TNF Receptor-Associated Factor 3) (N-Term) (ABIN501026) Immunocytochemistry of TRAF3 in HeLa cells with this product at 10 μg/ml.
Western Blotting (WB) image for anti-TRAF3 antibody (TNF Receptor-Associated Factor 3) (N-Term) (ABIN501026) Western blot analysis of TRAF3 in HeLa cell lysate with this product at (A) 2 and (B)...
Background publications van Eyndhoven, Gamper, Cho et al.: "TRAF-3 mRNA splice-deletion variants encode isoforms that induce NF-kappaB activation." in: Molecular immunology, Vol. 36, Issue 10, pp. 647-58, 1999 (PubMed).

Mosialos, Birkenbach, Yalamanchili et al.: "The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family." in: Cell, Vol. 80, Issue 3, pp. 389-99, 1995 (PubMed).

Cheng, Cleary, Ye et al.: "Involvement of CRAF1, a relative of TRAF, in CD40 signaling." in: Science (New York, N.Y.), Vol. 267, Issue 5203, pp. 1494-8, 1995 (PubMed).