Tetratricopeptide Repeat Domain 5 (TTC5) (C-Term) antibody

Details for Product No. ABIN501091
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Antigen
Synonyms TTC5, ttc5, wu:fi33h05, wu:fy81e07, zgc:112059, Strap, 5930437N14, AW743060
Epitope
C-Term
(14), (3), (1)
Reactivity
Human, Mouse (Murine)
(20), (9), (1), (1), (1)
Host
Rabbit
(19), (1)
Clonality
Polyclonal
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(20), (9), (7), (1), (1), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN501091
401.50 $
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Immunogen TTC5 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human TTC5.
Isotype IgG
Specificity This antibody detects TTC5
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse
Purification Affinity chromatography
Alternative Name TTC5
Background Tetratricopeptide repeat protein 5 (TTC5) is a member of a diverse group of functionally distinct proteins that are characterized by containing one or more tetratricopeptide repeats (1). Each motif consists of two anti-parallel a-helices such that tandem arrays of TPR motifs generate a right-handed helical structure with an amphipathic channel that may serve to accommodate the complementary region of a target protein. While the exact function of TTC5 remains unclear, it is thought that the TPR motifs serve to mediate protein-protein interactions such as those seen with protein chaperones HSP70 and HSP90 (2) and some proteins involved in cell stress response signaling pathways such as protein phosphatase 5 (3), suggesting that TTC5 may also function via protein-protein interactions mediated by its TPR motifs.Synonyms: TPR repeat protein 5, Tetratricopeptide repeat protein 5
Gene ID 91875
UniProt Q8N0Z6
Research Area Signaling
Application Notes ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Background publications Blatch, Lässle: "The tetratricopeptide repeat: a structural motif mediating protein-protein interactions." in: BioEssays : news and reviews in molecular, cellular and developmental biology, Vol. 21, Issue 11, pp. 932-9, 1999 (PubMed).

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