Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) antibody

Details for Product No. ABIN501094
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Antigen
Synonyms APO3L, DR3LG, TWEAK, Apo3l, Dr3l, Dr3lg, Tweak
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(61), (35), (10), (2)
Host
Rabbit
(42), (16), (13), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(10), (6)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(53), (30), (25), (17), (8), (8), (7), (4), (4), (2), (2), (2)
Pubmed 5 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN501094
401.50 $
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Immunogen Recombinant Human TWEAK.
Isotype IgG
Specificity This antibody detects TWEAK / TNFSF12.
Purification Peptide Affinity Chromatography
Alternative Name TWEAK / TNFSF12
Background TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane (1,2). TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis (3), induction of inflammatory cytokines (4), in addition to stimulation of apoptosis (5). The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains (1). Despite its predicted molecular weight of 27kDa, TWEAK may migrate at aberrant positions in SDS-PAGE.
Alternate names: APO3 ligand, APO3L, DR3LG, TNF-related weak inducer of apoptosis, Tumor necrosis factor ligand superfamily member 12
Gene ID 8742
NCBI Accession NP_003800
Application Notes ELISA. Western blot: 0.5 – 1 μg/ml. Immunohistochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Chicheportiche, Bourdon, Xu et al.: "TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis." in: The Journal of biological chemistry, Vol. 272, Issue 51, pp. 32401-10, 1998 (PubMed).

Lynch, Wang, Lund et al.: "TWEAK induces angiogenesis and proliferation of endothelial cells." in: The Journal of biological chemistry, Vol. 274, Issue 13, pp. 8455-9, 1999 (PubMed).

Yoshida, Matsui, Yamamoto et al.: "XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor." in: Cell, Vol. 107, Issue 7, pp. 881-91, 2002 (PubMed).

Chicheportiche, Chicheportiche, Sizing et al.: "Proinflammatory activity of TWEAK on human dermal fibroblasts and synoviocytes: blocking and enhancing effects of anti-TWEAK monoclonal antibodies." in: Arthritis research, Vol. 4, Issue 2, pp. 126-33, 2002 (PubMed).

Kaplan, Lewis, Shelden et al.: "The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 10, pp. 6020-9, 2002 (PubMed).

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