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Ectodysplasin A2 Receptor antibody (EDA2R)

Details for Product anti-EDA2R Antibody No. ABIN501133, Supplier: Log in to see
Antigen
  • EDA-A2R
  • EDAA2R
  • TNFRSF27
  • XEDAR
  • 9430060M22Rik
  • Xedar
  • RGD1564025
Reactivity
Human
84
15
15
Host
Rabbit
72
12
Clonality
Polyclonal
Conjugate
This Ectodysplasin A2 Receptor antibody is un-conjugated
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
68
29
11
10
10
3
1
Supplier
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Immunogen XEDAR antibody was raised against recombinant human XEDAR.
Isotype IgG
Specificity This antibody detects EDA2R / TNFRSF27.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Affiinity chromatography
Alternative Name EDA2R / TNFRSF27 (EDA2R Antibody Abstract)
Background X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2) (1). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kappaB and JNK pathways (2). Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis (3). The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment (3).Synonyms: EDA-A2 receptor, Tumor necrosis factor receptor superfamily member 27, UNQ2448/PRO5727/PRO34080, X-linked ectodysplasin-A2 receptor, XEDAR
Gene ID 60401
Application Notes ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistrry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Ectodysplasin A2 Receptor antibody (EDA2R) (ABIN501133) Immunohistochemistry of XEDAR in human skin tissue with this product at 10 μg/ml.
Western Blotting (WB) image for anti-Ectodysplasin A2 Receptor antibody (EDA2R) (ABIN501133) Western blot analysis of XEDAR in 293 cell lysate with this product at (A) 0.5, (B) 1...
Background publications Sinha, Chaudhary: "Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism." in: The Journal of biological chemistry, Vol. 279, Issue 40, pp. 41873-81, 2004 (PubMed).

Sinha, Zachariah, Quiñones et al.: "Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor." in: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 44953-61, 2002 (PubMed).

Yan, Wang, Hymowitz et al.: "Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors." in: Science (New York, N.Y.), Vol. 290, Issue 5491, pp. 523-7, 2000 (PubMed).