ZC3H12A antibody (Center)

Catalog No. ABIN501151

Product Details anti-ZC3H12A Antibody

Target: ZC3H12A (Zinc Finger CCCH-Type Containing 12A (ZC3H12A))

Binding Specificity: Center

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZC3H12A antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects human ZC3H12A.

Purification: Affinity chromatography

Immunogen: ZC3H12A antibody was raised against a 17 amino acid peptide near the center of human ZC3H12A.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ZC3H12A

Target: ZC3H12A (Zinc Finger CCCH-Type Containing 12A (ZC3H12A))

Alternative Name: ZC3H12A (ZC3H12A Products)

Synonyms: CGA antibody, MCPIP antibody, MCPIP1 antibody, RP3-423B22.1 antibody, dJ423B22.1 antibody, BC036563 antibody, Mcpip1 antibody, RGD1306776 antibody, chromogranin A antibody, zinc finger CCCH-type containing 12A antibody, zinc finger CCCH type containing 12A antibody, CHGA antibody, ZC3H12A antibody, Zc3h12a antibody

Background: ZC3H12A, also known as MCPIP, is an essential member of a family of novel CCCH-zinc finger proteins that regulate macrophage activation and may be involved in host immunity and inflammatory diseases. ZC3H12A has RNase activity that prevents some immune disorders by directly affecting the mRNA stability of interleukins such as IL-6 and IL12p40. Mice lacking the ZC3H12A gene suffered from severe anemia, and most dies within 12 weeks. Overexpression of ZC3H12A causes ER stress and induces a number of genes involved in apoptosis and autophagy, including JNK, PUMA, and beclin-1 in cardiac myoblasts, leading to cell death. ZC3H12A can also induce adipogenesis in 3T3-L1 pre-adipocytes in the absence of PPAPg, demonstrating the complex roles ZC3H12A plays.Synonyms: MCP-induced protein 1, MCPIP, MCPIP1, Ribonuclease ZC3H12A, Zinc finger CCCH domain-containing protein 12A

Gene ID: 80149

NCBI Accession: NP_079355

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of fat Cell Differentiation