ZSCAN4 antibody (C-Term)

Catalog No. ABIN501165

This anti-ZSCAN4 antibody is a Rabbit Polyclonal antibody detecting ZSCAN4 in WB, IHC (p) and IF. Suitable for Human, Mouse and Rat.

Quick Overview for ZSCAN4 antibody (C-Term) (ABIN501165)

Target: ZSCAN4 (Zinc Finger and SCAN Domain Containing 4 (ZSCAN4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZSCAN4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-ZSCAN4 Antibody

Binding Specificity: C-Term

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography

Immunogen: 18 amino acid peptide near the carboxy terminus of human ZSCAN4

Isotype: IgG

Application Details

Application Notes: ELISA. Immunohistochemistry on paraffin sections. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for ZSCAN4

Target: ZSCAN4 (Zinc Finger and SCAN Domain Containing 4 (ZSCAN4))

Alternative Name: ZSCAN4

Background: Zytotic genome activation (ZGA) is the first and most critical transition event from the maternal genetic to the embryonic genetic program and the major burst of ZGA occurs only in the late 2-cell stage. ZSCAN4 encodes a SCAN domain and four zinc finger domains and is expressed in late 2-cell embryos and embryonic stem cells. Loss-of-function studies using siRNA shows delays in the progression from the 2-cell to the 4-cell stage and subsequent embryo development. ZSCAN4 plays an important role in the preimplantation development. Also, ZSCAN4 is involved in telomere maintenance and long term genomic stability in ES cells, suggesting that ZSCAN4 may be of critical importance in maintaining pluripotency in replicating stem cells.Synonyms: ZNF494, Zinc finger and SCAN domain-containing protein 4, Zinc finger protein 494

Gene ID: 201516

NCBI Accession: NP_689890