Atrophin 1 antibody (N-Term)

Catalog No. ABIN501239

The Rabbit Polyclonal anti-Atrophin 1 antibody has been validated for WB. It is suitable to detect Atrophin 1 in samples from Human, Mouse, Rat, Rabbit, Cow, Dog, Horse and Pig.

Quick Overview for Atrophin 1 antibody (N-Term) (ABIN501239)

Target: Atrophin 1 (ATN1)

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Atrophin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Atrophin 1 Antibody

Binding Specificity: N-Term

Sequence: VSTSSSDGKA EKSRQTAKKA RVEEASTPKV NKQGRSEEIS ESESEETNAP

Predicted Reactivity: Cow: 93%, Dog: 93%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against ATN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ATN1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1190 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Atrophin 1

Target: Atrophin 1 (ATN1)

Alternative Name: ATN1

Background: Dentatorubral pallidoluysian atrophy is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion of a trinucleotide repeat within ATN1. The protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein.Dentatorubral pallidoluysian atrophy is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion of a trinucleotide repeat within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein.
Alias Symbols: B37, D12S755E, DRPLA, NOD, HRS
Protein Interaction Partner: WWOX, Dlg4, SIAH1, HINFP, LRP2, RBFOX1, EFEMP2, NOC2L, RCHY1, ZMYND8, RBFOX2, KAT6B, SSPO, RAD54L2, ZSWIM8, WDR5, WWP2, WWP1, RBPMS, SPAG5, FBLN5, BAIAP2, PSME3, CBFA2T2, CHRD, NCK2, LTBP4, RBM10, KAT6A, BAG6, PRRC2A, TRIP6, TEP1, SLIT1, SIAH2, PSMA3, PLS
Protein Size: 1190

Molecular Weight: 125 kDa

Gene ID: 1822

NCBI Accession: NM_001940, NP_001931

UniProt: P54259