Histone Deacetylase 8 (HDAC8) antibody
| Antigen |
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| Synonyms |
RPD3, HDACL1, 2610007D20Rik, RGD1562895, zgc:66196, wu:fd19a02, MGC80565, hdac8, HDAC8, MGC142318, ATHDA8, HDA08, HDA8, histone deacetylase 8, HISTONE DEACETYLASE 8, T27G7.14, T27G7_14 |
| Clonality |
Polyclonal |
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Host
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Reactivity
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 Alternatives Cow (Bovine), Human, Mouse (Murine), Rat (Rattus), Dog (Canine)
Human (65), Mouse (Murine) (46), Rat (Rattus) (42), Cow (Bovine) (21), Chicken (19), Horse (Equine) (18), Pig (Porcine) (18), Cat (Feline) (1), Dog (Canine) (1), Xenopus laevis (1), Zebrafish (1)
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Conjugate
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Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), PE,Cy5.5 (2), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
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Application
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| Catalog no. |
ABIN501306 |
| Quantity |
50 µg (Variants) |
| Price |
317.90 $ Plus shipping costs $45.00
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Bulk discount
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| Shipping to |
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| Availability |
Will be delivered in 2 to 3 Business Days |
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Alternative name
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HDAC8
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Gene ID
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HDAC8
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UniProt
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Q9BY41
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Immunogen
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The immunogen for anti-HDAC8 antibody: synthetic peptide directed towards the N terminal of human HDAC8
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Sequence
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MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASM VHSLIEAYAL
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Cross-Reactivity
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Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
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Format
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Lyophilized
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Reconstitution
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Add 50 µl of distilled water. Final anti-HDAC8 antibody concentration is 1 mg/ml.
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Description
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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
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Characteristics
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Antigen Size: 377 amino acids
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Molecular Weight
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42kDa
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Application Notes
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WB Suggested Anti-HDAC8 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Transfected 293T.
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Purification
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Affinity Purified
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Buffer
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PBS
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Storage (Long Term)
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For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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Storage (Short Term)
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Any unfrozen and/or unused material can be stored at 4°C for short term use (< 1 week), and should not be re-frozen.
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Research Area
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Cardiovascular, Hypertrophy, Transcription Factors, DNA/RNA, Wnt Signaling
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Restrictions
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For Research Use only
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Product
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Balasubramanian, Ramos, Luo et al.: "A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 22, Issue 5, pp. 1026-34, 2008 (PubMed).
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Alternatives for antigen "Histone Deacetylase 8 (HDAC8)", type "Antibodies"
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Hosts
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Rabbit (64), Mouse (3)
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Reactivities
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Human (65), Mouse (Murine) (46), Rat (Rattus) (42), Cow (Bovine) (21), Chicken (19), Horse (Equine) (18), Pig (Porcine) (18), Cat (Feline) (1), Dog (Canine) (1), Xenopus laevis (1), Zebrafish (1)
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Applications
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Western Blotting (WB) (39), ELISA (23), Immunofluorescence (IF) (23), Immunohistochemistry (IHC) (21), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (10), Immunoprecipitation (IP) (9), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Dot Blot (DB) (1), Immunoelectron Microscopy (IEM) (1)
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Conjugates
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Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), PE,Cy5.5 (2), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
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Epitopes
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pSer39 (12), N-Term (4), C-Term (3), AA 305-377 (1), pTyr594 (1)
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2013 BioMed Central Research Awards
