NMDAR2A antibody (Middle Region)

Catalog No. ABIN501364

This Rabbit Polyclonal antibody specifically detects NMDAR2A in WB and IHC. It exhibits reactivity toward Human, Rat, Mouse, Cow, Dog, Guinea Pig and Horse.

Quick Overview for NMDAR2A antibody (Middle Region) (ABIN501364)

Target: NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))

Reactivity: Human, Rat, Mouse, Cow, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NMDAR2A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-NMDAR2A Antibody

Binding Specificity: Middle Region

Sequence: DKIYTIDGEK EPGFHLDPPQ FVENVTLPEN VDFPDPYQDP SENFRKGDST

Predicted Reactivity: Cow: 77%, Dog: 93%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 79%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against GRIN2A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human GRIN2A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1464 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for NMDAR2A

Target: NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))

Alternative Name: GRIN2A

Background: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D).N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: NMDAR2A, NR2A, EPND, GluN2A
Protein Interaction Partner: Nedd4, SPTAN1, DLG4, DLG1, UBC, GRIN1, ARHGAP32, CAMK2B, GRIN3B, GRIN3A, DLGAP1, CAMK2A, DLG2, AP1M1, INADL, IL16, AP4M1, RGS3, PTK2B, DLG3, CASK, SRC, PRKCA, PTPN4, PLCG1, GRIN2A, FYN, CDK5, ACTN1, Dlgap2,
Protein Size: 1464

Molecular Weight: 163 kDa

Gene ID: 2903

NCBI Accession: NM_000833, NP_000824

UniProt: Q12879

Pathways: Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity